Inhibition of rat liver cholesterol esterase by local anaesthetics.

Biochimica Et Biophysica Acta
J R Traynor, H Kunze

Abstract

1. A number of local anaesthetics was shown to inhibit rat liver cholesterol esterase activity towards radioactively labelled cholesterol oleate. The anaesthetics inhibited in the order dibucaine greater than chlorpromazine greater than tetracaine greater than benzocaine greater than procaine greater than lidocaine greater than cocaine. 2. The mode of inhibition was seen to be non-competitive with respect to the substrate and is probably independent of any involvement of Ca2+. 3. The inhibition by tetracaine is partially reversed by sodium deoxycholate. However, all ionic and non-ionic detergents studied, sodium deoxycholate, sodium taurocholate, Triton X-100, and cetyltrimethylammonium bromide are capable of inhibiting the rat liver cholesterol esterase in a concentration dependent manner. Only sodium taurocholate stimulates enzymic activity.

References

Sep 19, 1974·Biochimica Et Biophysica Acta·H KunzeW Vogt
Oct 5, 1972·Biochimica Et Biophysica Acta·K T Stokke
Nov 1, 1972·The Biochemical Journal·K Siddle, C N Hales
Apr 18, 1972·Biochimica Et Biophysica Acta·D Papahadjopoulos
Oct 1, 1965·Physiological Reviews·D S Goodman
Jun 1, 1965·Biochimica Et Biophysica Acta·G W VahounyC R Treadwell

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Citations

Feb 1, 1981·Lipids·C Madhosingh, W Orr
Feb 23, 1976·Biochimica Et Biophysica Acta·J R Traynor, H Kunze
Jul 20, 1976·Biochimica Et Biophysica Acta·H KunzeM Wurl
Jan 1, 1988·Annales Françaises D'anesthèsie Et De Rèanimation·P BendrissP Erny

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