PMID: 11903499Mar 21, 2002Paper

Inhibition of rat parotid and submandibular gland functions by ofloxacin, a fluoroquinolone antibiotic

Fundamental & Clinical Pharmacology
M Abdollahi, Z Isazadeh

Abstract

While fluoroquinolones are widely used in the treatment of various infectious disease, not enough attention has been paid to their adverse effects on salivary glands functions. In the present study, the effects of ofloxacin, a fluoroquinolone antibiotic, on rat parotid and submandibular gland functions, were examined in an acute experiment. Ofloxacin (OFLX) was administered intraperitoneally at various doses (20, 40, and 80 mg/kg). Pure parotid and submandibular saliva were collected intraorally by microployethylene tubes under anaesthesia using a dissecting microscope. Flow rate, amylase activity, total protein, and calcium concentrations were reduced by all doses of OFLX (20, 40, 80 mg/kg, P < 0.01) in parotid saliva. In parotid saliva, sodium and potassium were increased by doses of 20 and 40 mg/kg (P < 0.01) and 20, 40, 80 mg/kg (P < 0.01) respectively. In submandibular saliva, flow rate, total protein and calcium concentrations were significantly reduced by all doses (20, 40, 80 mg/kg, P < 0.01). Sodium and potassium concentrations were also increased by a dose of 80 mg/kg, (P < 0.05) in submandibular saliva. It is concluded that ofloxacin inhibits rat salivary gland functions, which might be observed as a side-effect in h...Continue Reading

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Citations

Nov 26, 2009·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Barna KelenteyTimea Bacskai
May 21, 2003·Human & Experimental Toxicology·Mohammad AbdollahiAmir A Yaaghoubi
Jun 14, 2002·Acta Veterinaria Hungarica·Z JanjecićD Zupanić
Dec 22, 2020·PloS One·Mohammad ShahidullahNicholas Anthony Delamere

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