Inhibition of rat vas deferens contractions by flavonoids in-vitro

The Journal of Pharmacy and Pharmacology
Raffaele CapassoFrancesca Borrelli

Abstract

Flavonoids are a large heterogeneous group of benzo-gamma-pyrone derivatives, which are abundantly present in our diet. In this study we investigated the effect of ten flavonoids (quercetin, kaempferol, morin, galangin, rutin, apigenin, flavone, naringenin, hesperitin and silybin) on the contractile response elicited by electrical field stimulation in the rat isolated vas deferens. All flavonoids tested inhibited vas deferens contractions. The relative order of potency of the tested flavonoids was naringenin > hesperitin > morin > kaempferol > apigenin > silybin > flavone > rutin > quercetin > galangin. Analysis of the chemical structures showed that the saturation of C-2-C-3 double bond and the presence of hydroxyl groups on the flavonoidic scaffold play an important role in the activity of flavonoids.

References

Feb 25, 1983·Pharmaceutisch Weekblad. Scientific Edition·C O Van Den Broucke, J A Lemli
Jul 15, 1999·Journal of Ethnopharmacology·M ItoigawaH Furukawa
Jul 27, 1999·Life Sciences·G Di CarloF Capasso
Jan 29, 2003·The Journal of Nutritional Biochemistry·Kelly E. HeimDennis J. Bobilya
Apr 23, 2003·Life Sciences·Raffaele Capasso, Nicola Mascolo
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Dec 2, 2004·Nutrition and Cancer·Marian L Neuhouser
Apr 30, 2005·Current Opinion in Plant Biology·Loverine P Taylor, Erich Grotewold

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Citations

Aug 2, 2007·Biological & Pharmaceutical Bulletin·Shi-Fu MoLing-Dong Kong
Jul 5, 2013·Phytotherapy Research : PTR·Barbara RomanoFrancesca Borrelli
Oct 9, 2008·European Journal of Pharmacology·Smain AmiraFlavia Mulè

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