PMID: 3756522Sep 24, 1986Paper

Inhibition of release of neurohypophysial hormones by endogenous opioid peptides in pregnant and parturient rats

Brain Research
R D HartmanJ Y Summy-Long

Abstract

Naloxone, an opiate receptor antagonist, was used to determine whether opioid peptides modulate release of oxytocin (OT) or vasopressin (AVP) in the rat after expulsion of the fetus, i.e. parturition. We measured the concentrations of AVP and OT in plasma and in the neurointermediate lobe of the pituitary of pregnant rats given naloxone (5 mg/kg, s.c.) or saline on day 20 of gestation, and on day 21 either before or during the expulsive stage of labor. Non-pregnant rats in diestrus were given naloxone for comparison. On days 20 and 21 of gestation, before the onset of parturition, plasma [AVP] but not [OT] was elevated, compared to the non-pregnant controls. After delivery of the first two pups, plasma [OT] approximately doubled, whereas plasma [AVP] remained unchanged. Blocking the action of endogenous opioid peptides with naloxone caused an elevation of plasma [OT] in pregnant animals on days 20 and 21 of gestation and during parturition. Naloxone, however, did not alter plasma [AVP] in either parturient or preparturient animals. In contrast, [AVP], but not [OT], was increased in plasma of non-pregnant rats given naloxone. The content of OT in the neuro-intermediate lobe was similar in pregnant and non-pregnant rats and was u...Continue Reading

References

Mar 1, 1978·Proceedings of the Society for Experimental Biology and Medicine·J Haldar, W H Sawyer
Mar 18, 1977·Brain Research·R Simantov, S H Snyder
May 1, 1975·The Journal of Endocrinology·K BoerD F Swaab
Apr 1, 1973·The Journal of Endocrinology·W E AllenM L Forsling
Feb 1, 1974·The Journal of Clinical Endocrinology and Metabolism·W R SkowskyD A Fisher
Dec 1, 1969·Biology of Reproduction·A R Fuchs
Jun 1, 1970·Biology of Reproduction·A R Fuchs, V F Poblete
Apr 2, 1982·Science·S J WatsonT B van wimersma Griedanus
Sep 5, 1980·European Journal of Pharmacology·B Lutz-Bucher, B Koch
Jan 1, 1983·Life Sciences·J E FletcherR G Hill
Apr 1, 1984·The Journal of Clinical Investigation·W M BarronM D Lindheimer
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J F RehfeldN A Thorn
Oct 1, 1983·Neuroendocrinology·R E LangW Rascher
Oct 1, 1981·The Journal of Clinical Endocrinology and Metabolism·R D LeakeD A Fisher
Oct 1, 1980·Endocrinology·A R Fuchs, M Y Dawood

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Citations

Jun 1, 1988·Brain Research Bulletin·R J BicknellB G Zhao
Jun 1, 1993·Journal of Neuroendocrinology·A J DouglasR J Bicknell
Apr 1, 1994·Journal of Neuroendocrinology·E MaF Ellendorff
May 1, 2001·American Journal of Veterinary Research·D C BrownJ A Amico
Mar 24, 2006·The European Journal of Neuroscience·Paula J BruntonJohn A Russell
Jun 12, 1992·Annals of the New York Academy of Sciences·G F Jirikowski
Feb 26, 2010·Journal of the Royal Society, Interface·Junfeng JiaChangsheng Liu
Sep 14, 2019·Endocrinology·Masahide YoshidaKatsuhiko Nishimori
Dec 21, 2019·The Mental Health Clinician·Kristin Harter
Oct 1, 1988·Pharmacology & Toxicology·S GrellB Fjalland
Oct 1, 1994·Journal of Endocrinological Investigation·M MaggiT Susini
Jun 28, 2001·Physiological Reviews·J P BurbachH Gainer
May 4, 2017·Proceedings of the National Academy of Sciences of the United States of America·Olga Dal MonteSteve W C Chang
Jan 1, 1989·Neuroscience and Biobehavioral Reviews·I S ZagonP J McLaughlin

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