Inhibition of Rho-kinase in the brainstem augments baroreflex control of heart rate in rats

Hypertension
Koji ItoKenji Sunagawa

Abstract

The Rho/Rho-kinase pathway in the nucleus tractus solitarii (NTS) of the brain stem contributes to blood pressure regulation. Activation of this pathway might be involved in the central nervous system mechanisms of hypertension. The aim of the present study was to determine whether baroreflex control of heart rate is altered by inhibition of Rho-kinase in the NTS. Adenovirus vectors encoding dominant-negative Rho-kinase or beta-galactosidase were transfected into the nucleus tractus solitarii of Wistar Kyoto rats (WKY) and spontaneously hypertensive rats (SHR). Baroreflex control of heart rate was examined by changing arterial pressure with an intravenous infusion of phenylephrine or sodium nitroprusside. The maximum gain of baroreflex control of heart rate was attenuated in SHR compared with WKY before the gene transfer. Transfection of adenovirus vectors encoding dominant-negative Rho-kinase significantly augmented the maximum gain in both WKY and SHR. The extent of this augmentation, however, was greater in SHR than in WKY. After treatment with metoprolol, the maximum gain was significantly decreased in rats transfected with adenovirus vectors encoding dominant-negative Rho-kinase, but not in nontransfected rats. In contrast...Continue Reading

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Citations

Jul 16, 2013·Current Hypertension Reports·Olaf Grisk
Jan 6, 2005·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Yoshitaka Hirooka, Hiroaki Shimokawa
Aug 9, 2005·Expert Opinion on Therapeutic Targets·Erding Hu, Dennis Lee
May 14, 2005·Expert Review of Cardiovascular Therapy·Yoshiyuki Rikitake, James K Liao
Sep 3, 2008·Autonomic Neuroscience : Basic & Clinical·Koji ItoKenji Sunagawa
Apr 18, 2006·Autonomic Neuroscience : Basic & Clinical·Yoshitaka Hirooka
Jul 9, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Hiroaki Shimokawa, Akira Takeshita
May 7, 2020·American Journal of Hypertension·Yoshitaka Hirooka

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