Inhibition of S-warfarin metabolism by nonsteroidal antiinflammatory drugs in human liver microsomes in vitro

Biological & Pharmaceutical Bulletin
T TakigawaH Ogata

Abstract

We studied the inhibition of S-warfarin metabolism by nonsteroidal antiinflammatory drugs (NSAIDs) in human liver microsomes in vitro. After screening for potential inhibitors among ten NSAIDs using human recombinant cytochrome P450, inhibition kinetic parameters were estimated using human liver microsomes. Phenylbutazone and bucolome were suggested to increase the unbound steady-state level of S-warfarin about four- and five-fold, respectively, as estimated from these metabolic parameters.

Citations

Apr 18, 2001·Journal of Clinical Pharmacology·K MatsumotoM Shibakawa
Mar 6, 2012·Expert Opinion on Drug Metabolism & Toxicology·Justin D Lutz, Nina Isoherranen
Dec 22, 2010·International Heart Journal·Yuko HatakeyamaTohru Izumi

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