PMID: 11924526Apr 2, 2002Paper

Inhibition of septic shock in mice by an oligopeptide from the beta-chain of human chorionic gonadotrophin hormone

Human Immunology
Nisar A KhanRobbert Benner

Abstract

Human chorionic gonadotrophin (hCG) is a heterodimeric placental glycoprotein hormone required in pregnancy. In human pregnancy urine and in commercial hCG preparations (c-hCG) it occurs in a variety of forms, including breakdown products. Several reports have suggested modulation of the immune system by intact hormone, but such effects of breakdown products have not been reported. In a related article (Hum Immunol 62:1315, 2001), it is reported that a 400-2000 Dalton (Da) fraction from c-hCG and from human pregnancy urine inhibits Th1-mediated diabetes in NOD mice. The active component(s) were called natural (immuno)modulatory pregnancy factor(s) (NMPF). This study reports that a single treatment with the same low molecular weight NMPF fraction up to 24-h after high dose lipopolysaccharide (LPS) injection inhibited septic shock in mice. This counteracting effect of NMPF paralleled the downregulation of the effects of LPS on the production of macrophage migration inhibitory factor (MIF) by spleen cells, on the plasma level of liver aminotransferase, and on the expression of several splenic lymphocyte and macrophage surface markers. Based on the primary structure of the beta-chain of hCG a synthetic hexapeptide Valine-Leucin-Pro...Continue Reading

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Citations

Jul 28, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nisar A KhanRon W F de Bruin
Mar 17, 2006·Critical Care Medicine·Sven K TschoekeLyle L Moldawer
Jun 15, 2005·Scandinavian Journal of Immunology·R Benner, N A Khan
Apr 14, 2006·International Journal of Immunogenetics·V VettriselviV Jayanth
Jul 13, 2007·Journal of Leukocyte Biology·Hui WanRebecca C M Kiekens
Mar 26, 2019·Clinical and Translational Gastroenterology·Janine van der GiessenGwenny M Fuhler
Mar 30, 2019·British Journal of Clinical Pharmacology·Roger van GroenendaelPeter Pickkers
Dec 24, 2010·Critical Care Medicine·David J van Westerloo
Oct 12, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marten van der ZeeWillem A Dik
Aug 8, 2008·Journal of Leukocyte Biology·Hui WanMarjan A Versnel

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