PMID: 7541692Apr 1, 1995Paper

Inhibition of serum-induced proliferation of bovine tracheal smooth muscle cells in culture by heparin and related glycosaminoglycans

British Journal of Pharmacology
S KilfeatherC P Page

Abstract

1. The effect of heparin and related glycosaminoglycans on bovine airway smooth muscle proliferation has been investigated. 2. Foetal bovine serum stimulated division of bovine trachealis smooth muscle cells in a concentration-dependent fashion at concentrations between 1 and 30%. 3. Heparin (0.1-100 micrograms ml-1), heparan sulphate (0.1-100 micrograms ml-1) and fragmin (0.1-100 micrograms ml-1) inhibited smooth muscle division in a concentration-dependent fashion between 0.1-100 micrograms ml-1. A heparin disaccharide did not exhibit inhibition of division at 100 micrograms ml-1. 4. Dextran sulphate at molecular weights of 5 x 10(3) and 5 x 10(5) concentration-dependently inhibited division between 0.1-100 micrograms ml-1. Dextran without sulphation did not exhibit inhibition of division at 100 micrograms ml-1. 5. The magnitude of inhibition of proliferation did not reach 100% for any compounds examined at concentrations up to 100 micrograms ml-1 during incubations for 5 and 14 days. IC50 values for inhibition of proliferation ranged between 1-5 micrograms ml-1. 6. These findings suggest that heparin and related glycosaminoglycans inhibit bovine airway smooth muscle cell division.

References

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Citations

Feb 11, 2000·The Journal of Allergy and Clinical Immunology·C Page
Jan 7, 2014·Expert Opinion on Investigational Drugs·Madhur D ShastriRahul P Patel
May 27, 2009·International Journal of Pharmaceutics·F A Oyarzun-AmpueroM J Alonso
Aug 29, 2013·ISRN Pharmacology·Clive Page
Mar 17, 2000·Pulmonary Pharmacology & Therapeutics·Z Diamant, C P Page
Apr 18, 2008·European Journal of Pharmacology·Reinoud GosensHerman Meurs
Jul 18, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ayca YildizMark Gumbleton
Jul 13, 2001·Pulmonary Pharmacology & Therapeutics·R Lever, C Page
Jul 13, 2001·Pulmonary Pharmacology & Therapeutics·A G Stewart
Dec 22, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J C In 't VeenE H Bel
May 3, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A J KnoxA Hamad
Dec 7, 2013·Integrative Biology : Quantitative Biosciences From Nano to Macro·Qi Ying LeanNuri Gueven
Jul 1, 1997·Canadian Journal of Physiology and Pharmacology·M B HershensonJ Li
Dec 17, 2015·Pharmacological Reviews·Barbara MulloyClive P Page
May 22, 2003·The American Journal of Pathology·Holly R MasonJohn J Castellot

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