Inhibition of serum-stimulated mitogen activated protein kinase by 1alpha,25(OH)2-vitamin D3 in MCF-7 breast cancer cells

Journal of Cellular Biochemistry
D A CapiatiR Boland

Abstract

1alpha,25-Dihydroxyvitamin D3 [1alpha,25(OH)2D3], the hormonally active form of vitamin D3, has been shown to be a potent negative growth regulator of breast cancer cells both in vitro and in vivo. 1alpha,25(OH)2D3 acts through two different mechanisms. In addition to regulating gene transcription via its specific intracellular receptor (vitamin D receptor, VDR), 1alpha,25(OH)2D3 induces rapid, non-transcriptional responses involving activation of transmembrane signal transduction pathways, like growth factors and peptide hormones. The mechanisms that mediate the antiproliferative effects of 1alpha,25(OH)2D3 in breast cancer cells are not fully understood. Particularly, there is no information about the early non-genomic signal transduction effectors modulated by the hormone. The present study shows that 1alpha,25(OH)2D3 rapidly inhibits serum induced activation of ERK-1 and ERK-2 MAP kinases. The tyrosine kinase Src is involved in the pathway leading to activation of ERK 1/2 by serum. Furthermore, 1alpha,25(OH)2D3 increases the tyrosine-phosphorylated state of Src and inhibits its kinase activity, while induces the association of the VDR with Src, either in the presence or absence of serum. In parallel, the hormone rapidly inc...Continue Reading

References

May 1, 1992·Journal of Cellular Biochemistry·A R de Boland, I Nemere
Apr 13, 1989·The New England Journal of Medicine·H ReichelA W Norman
Dec 1, 1988·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P P Minghetti, A W Norman
Mar 1, 1989·The American Journal of the Medical Sciences·Y SuzukiL V Avioli
Apr 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·G Superti-Furga, S A Courtneidge
Mar 1, 1995·Trends in Biochemical Sciences·E Cano, L C Mahadevan
Nov 1, 1994·Trends in Biochemical Sciences·R J Davis
Jun 7, 1996·Biochimica Et Biophysica Acta·M T Brown, J A Cooper
Jan 22, 1998·Current Opinion in Structural Biology·F Sicheri, J Kuriyan
Aug 15, 1998·Biochemical and Biophysical Research Communications·I Nemere, M C Farach-Carson
Oct 23, 1998·Molecular and Cellular Endocrinology·L VerlindenR Bouillon
Mar 19, 1999·Molecular and Cellular Biology·H J Schaeffer, M J Weber
Jun 3, 1999·The Journal of Cell Biology·R A HallR J Lefkowitz
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·L M LuttrellR J Lefkowitz
Jul 31, 2001·Molecular and Cellular Endocrinology·P MonjeR Boland
Mar 27, 2002·Endocrine-related Cancer·K W Colston, C Mørk Hansen
May 17, 2002·The Journal of Nutritional Biochemistry·Rajendra G. Mehta, Rajeshwari R. Mehta
May 22, 2002·Biochimica Et Biophysica Acta·Margaret C Frame
Nov 5, 2002·Biochemical and Biophysical Research Communications·Anthony W NormanJune E Bishop
Mar 26, 2003·The Journal of Steroid Biochemistry and Molecular Biology·JoEllen WelshCarmen J Narvaez
Nov 19, 2003·Molecular and Cellular Biochemistry·Pratik Banerjee, Malay Chatterjee

❮ Previous
Next ❯

Citations

Aug 3, 2012·Chinese Journal of Cancer·Su-Ping ZhangJian-Rong Wang
Apr 5, 2011·Molecular and Cellular Endocrinology·Claudia BuitragoRicardo Boland
Aug 26, 2010·Fertility and Sterility·Chakradhari SharanAyman Al-Hendy
Apr 12, 2006·Oncogene·S S ShethA J Lusis
Jul 17, 2008·The Journal of Biological Chemistry·Jianrong WangSamantha Spindel
Feb 9, 2007·Journal of Cellular Biochemistry·Meggan E ValranceJoellen Welsh
Jul 9, 2005·Trends in Endocrinology and Metabolism : TEM·Ricardo BolandAna Russo De Boland

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.