PMID: 6539635Jun 3, 1984Paper

Inhibition of sexual behavior in female guinea pigs by a progestin receptor antagonist

Brain Research
T J Brown, J D Blaustein

Abstract

The new steroidal progestin receptor antagonist, RU 38486, was used to determine if progesterone-facilitation of sexual behavior in female guinea pigs requires interaction of the hormone with neural progestin receptors. Five milligrams but not 0.5 mg RU 38486 inhibits the expression of sexual behavior in ovariectomized, estrogen-primed guinea pigs treated with 0.1 mg progesterone. This inhibition can be overcome by administration of a large dose of progesterone, suggesting that the drug-effect is specific to the progestin receptor system. RU 38486 binds, in vitro, to progestin receptors and decreases the availability of hypothalamic progestin receptors in estrogen-treated guinea pigs. These studies provide strong evidence that progesterone interaction with intracellular neural progestin receptors mediates the facilitation of sexual behavior by progesterone in female guinea pigs.

Citations

Oct 27, 1987·European Journal of Pharmacology·S D MendelsonB B Gorzalka
Jan 1, 1987·Physiology & Behavior·I U VathyR J Barfield
Apr 1, 1991·Physiology & Behavior·C A Lisciotto, J F DeBold
Feb 1, 1989·Pharmacology, Biochemistry, and Behavior·J E ThorntonH H Feder
Jan 1, 1985·Neurochemistry International·M Warembourg
Nov 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·S W LawJ H Clark
Jun 28, 2003·Brain Research. Molecular Brain Research·Roderick E M ScottDonald W Pfaff
Mar 29, 2012·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·S K ManiG Anesetti
Aug 1, 1990·Journal of Neuroendocrinology·H Coirini, B S McEwen
Oct 30, 2008·PloS One·Catherine J Auger, Robin M Forbes-Lorman
Apr 26, 2012·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Joanna M BiazikMichael B Thompson
Feb 13, 1986·Biochemical and Biophysical Research Communications·J A Creba, M Karobath
Aug 14, 2003·Scandinavian Journal of Psychology·Shaila Mani
Mar 22, 2001·Frontiers in Neuroendocrinology·J E LevineM Szabo
Jan 1, 1986·Annals of the New York Academy of Sciences·I T Landau
Dec 25, 2004·Endocrinology·Jill B BeckerElizabeth Young
Mar 3, 2004·Annals of the New York Academy of Sciences·Jeffrey D Blaustein
Jan 1, 1986·Annals of the New York Academy of Sciences·J D Blaustein
Apr 27, 2021·Neuroscience Letters·Marcos García-JuárezOscar González-Flores

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.