PMID: 9416770Jan 1, 1997Paper

Inhibition of shear stress-induced platelet aggregation by cilostazol, a specific inhibitor of cGMP-inhibited phosphodiesterase, in vitro and ex vivo

Life Sciences
N MinamiM Nishikawa

Abstract

Cilostazol(6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)-butoxy]-3,4- dihydro-2(1H)-quinolinone) selectively inhibits cGMP-inhibited phosphodiesterase (PDE3) and is a potent inhibitor of platelet aggregation induced by various agonists. Effect of cilostazol on shear stress-induced human platelet aggregation (SIPA) was examined in vitro and ex vivo. Cilostazol inhibited SIPA dose-dependently in vitro. The IC50 value of cilostazol for inhibition of SIPA was 15 +/- 2.6 microM (m +/- SE, n=5), which was very similar to that (12.5 +/- 2.1 microM) for inhibition of ADP-induced platelet aggregation. Cilostazol potentiates the inhibition of SIPA by PGE1 and enhances its ability to increase cAMP concentrations. A single oral adminstration of 100 mg cilostazol to healthy volunteers produced a significant inhibition of SIPA. This study demonstrates that cilostazol is an effective inhibitor of SIPA, which may be important for the prevention and the treatment of arterial occlusive diseases.

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Citations

Apr 2, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·Masahiro YasutakeHirokazu Hayakawa
Apr 26, 2003·American Journal of Respiratory Cell and Molecular Biology·Zhiqian WangRodney A Rhoades
Nov 6, 2015·International Journal of Molecular Sciences·Meng MengDaojun Cheng
Apr 27, 2001·Expert Opinion on Investigational Drugs·J Geiger
Mar 24, 2015·Neurological Research·Nobutaka HorieIzumi Nagata
Jun 29, 2004·European Journal of Pharmacology·Tohru NojiHideaki Kusaka
Jan 21, 2011·The Cochrane Database of Systematic Reviews·Ayeesha K KamalBhojo A Khealani
Aug 1, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Amy E BaekDavid J Pinsky
Jun 13, 2020·Platelets·Fawaz O Alenazy, Mark R Thomas
Feb 24, 2001·The Annals of Pharmacotherapy·M P Reilly, E R Mohler
Jan 20, 2004·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Therese M Chapman, Karen L Goa
Jun 9, 2011·British Journal of Clinical Pharmacology·Paolo GreseleEmanuela Falcinelli

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