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Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology

Neurobiology of Disease

Mar 26, 2009

Fiona E McAlpineMalu G Tansey

Abstract

Microglial activation and overproduction of inflammatory mediators in the central nervous system (CNS) have been implicated in Alzheimer's disease (AD). Elevated levels of the pro-inflammatory cytokine tumor necrosis factor (TNF) have been reported in serum and post-mortem brains of pat...read more

Mentioned in this Paper

Hippocampus (Brain)
Founder Mice, Transgenic
Tumor Necrosis Factor-alpha
Subfamily lentivirinae
Inflammation
Metabolic Inhibition
Dominant-Negative Mutation
Insula of Reil
Recombinants
Alzheimer's Disease Pathway Kegg
2
132
Paper Details
References
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  • Citations81
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Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology

Neurobiology of Disease

Mar 26, 2009

Fiona E McAlpineMalu G Tansey

PMID: 19320056

DOI: 10.1016/j.nbd.2009.01.006

Abstract

Microglial activation and overproduction of inflammatory mediators in the central nervous system (CNS) have been implicated in Alzheimer's disease (AD). Elevated levels of the pro-inflammatory cytokine tumor necrosis factor (TNF) have been reported in serum and post-mortem brains of pat...read more

Mentioned in this Paper

Hippocampus (Brain)
Founder Mice, Transgenic
Tumor Necrosis Factor-alpha
Subfamily lentivirinae
Inflammation
Metabolic Inhibition
Dominant-Negative Mutation
Insula of Reil
Recombinants
Alzheimer's Disease Pathway Kegg
2
132

Similar Papers Found In These Feeds

Related Papers

Paper Details
References
  • References38
  • Citations81
1234
  • References38
  • Citations81
12345...
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