PMID: 6974866Jul 1, 1981Paper

Inhibition of specific cell-mediated cytotoxicity by monoclonal antibodies to human T cell antigens

Proceedings of the National Academy of Sciences of the United States of America
C D Platsoucas, R A Good

Abstract

Human T lymphocyte subpopulations recently have been defined by monoclonal antibodies that recognize cell-surface antigens selectively expressed on functionally distinct T cell subsets. The majority (approximately 90%) of the peripheral blood sheep erythrocyte-rosette-forming cells carry the OKT3 antigen. Helper cells are OKT4(+), whereas cytotoxic/suppressor cells are OKT5(+) and OKT8(+). We investigated the effect of several monoclonal antibodies recognizing T cell antigens on certain proliferative responses of T cells and on the effector phase of the specific T cell-mediated cytotoxicity generated in mixed lymphocyte culture (MLC). In the absence of added complement, (i) OKT3 and OKT4 monoclonal antibodies inhibited the proliferative response to phytohemagglutinin (PHA), (ii) OKT3 monoclonal antibody inhibited the proliferative response to allogeneic cells in MLC, and (iii) OKT3 monoclonal antibody significantly and regularly inhibited the effector phase of the specific T cell-mediated cytotoxicity against allogeneic targets (P < 0.001) in a concentration-dependent manner. The OKT5 and OKT8 monoclonal antibodies, again in the absence of complement, inhibited moderately the specific cell-mediated cytotoxicity. This inhibition...Continue Reading

References

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Citations

Jun 1, 1991·Cancer Metastasis Reviews·C D Platsoucas
Jul 1, 1994·Transplant International : Official Journal of the European Society for Organ Transplantation·D AbramowiczP Vereerstraeten
Sep 1, 1992·Transplant International : Official Journal of the European Society for Organ Transplantation·K J Parlevliet, P T Schellekens
Jan 1, 1982·Springer Seminars in Immunopathology·M C MingariL Moretta
Dec 1, 1987·Veterinary Immunology and Immunopathology·A J TealeN D MacHugh
May 1, 1983·Human Immunology·R L Sparrow, I F McKenzie
Mar 1, 1987·Human Immunology·H C Oettgen, C Terhorst
May 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J AntelB G Arnason
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·F Sanchez-MadridT A Springer
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·A de la HeraC Martinez
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·C G IoannidesC D Platsoucas
Apr 1, 1983·The Journal of Experimental Medicine·M Goto, N J Zvaifler
Oct 1, 1985·The Journal of Experimental Medicine·L LefrancoisM J Bevan
Jan 1, 1985·Hybridoma·E De Nardin, N Tanigaki
Jan 1, 1988·The American Review of Respiratory Disease·G SemenzatoG Marcer
Nov 1, 1992·American Journal of Obstetrics and Gynecology·R S FreedmanC D Platsoucas
Sep 1, 1987·Kidney International·M SuthanthiranK H Stenzel
Apr 15, 1983·Cellular Immunology·M RosenkoetterJ J Oger

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