PMID: 591113Jan 1, 1977

Inhibition of specific immune responses by feeding protein antigens

International Archives of Allergy and Applied Immunology
D G HansonC A Roy


A profound and long-lasting state of specific immune unresponsiveness may be induced in adult inbred mice given a single dose of protein immunogens--such as ovalbumin or hemocyanin--by the digestive route. The degree of unresponsiveness induced by intragastric exposure to ovalbumin could not be achieved by intravenous injection of deaggregated ovalbumin solutions across a wide range of doses. Unresponsiveness induced by intragastric exposure to hapten-protein conjugates is specific to the carrier protein.


Aug 1, 1995·International Journal for Parasitology·A CuisonY Nakajima
Nov 1, 1979·Veterinary Immunology and Immunopathology·T J NewbyF J Bourne
Jun 8, 2002·Toxicology Letters·R PietersS Nierkens
Sep 1, 1980·The Journal of Experimental Medicine·J A MattinglyC A Janeway
Jun 28, 2012·Clinical & Developmental Immunology·Bo JinAnthony E T Yeo
Sep 29, 2011·Clinical & Developmental Immunology·Bernardo Sgarbi Reis, Daniel Mucida
Jan 10, 2012·Annual Review of Immunology·Angelina M Bilate, Juan J Lafaille
Jul 1, 2014·Human Immunology·Adam S A Gracon, David S Wilkes
May 1, 1996·Journal of Neuroimmunology·K A Kelly, C C Whitacre
Dec 15, 2015·Immunobiology·Raquel Alves CostaCláudia Rocha Carvalho
Oct 22, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Henry Yim Wu
Apr 1, 1997·Medical Hypotheses·J Eldor
Aug 1, 1984·The Journal of Surgical Research·W E KoisD C Dafoe
Feb 13, 2013·Cellular Immunology·Archimedes Barbosa Castro-JuniorN M Vaz
Feb 15, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·B A VerdolinC R Carvalho
Mar 16, 2017·Immunology·Thiago Anselmo CantarutiCláudia Rocha Carvalho
May 1, 1978·Medical Hypotheses·N M Vaz, F J Varela
Feb 1, 1996·Baillière's Clinical Rheumatology·M F Kagnoff
Jun 29, 2006·Journal of Nutritional Science and Vitaminology·Alizadeh MohammadTohru Sakai
Jan 1, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chantal KuhnHoward L Weiner
Jun 1, 1994·Scandinavian Journal of Immunology·C R CarvalhoN M Vaz
Jan 1, 1993·European Journal of Immunology·J D PetersonS D Miller
Jan 1, 1985·Scandinavian Journal of Gastroenterology. Supplement·C O Elson
Jan 1, 1990·Clinical and Experimental Immunology·R B JohnsonJ H Skerritt
Jan 1, 1982·Annals of the New York Academy of Sciences·M F Kagnoff
Apr 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Karen M SmithPaul Garside
Oct 25, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·C A BlackR P Edwards
Jan 1, 1993·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·L A HansonU Dahlgren
Mar 1, 1996·Clinical and Experimental Immunology·D C Wraith
Aug 1, 1986·The American Journal of Physiology·P R HarmatzW A Walker

Related Concepts

Antibody Formation
Natural Immunosuppression
Injections, Intraperitoneal
Intravenous Injections
Intubation, Nasogastric
Mice, Inbred C57BL
Mice, Inbred DBA

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.