Inhibition of spermatogenesis in house rat (Rattus rattus Rufescens) following the administration of alpha- chlorohydrin

Andrologia
V P Dixit, M Agrawal

Abstract

Chronic administration of alpha-chlorohydrin (25 mg/kg body wt.) caused lesions in the testis of house rat. The changes in the germ cells were degenerative. The seminiferous tubules and Leydig cell nuclear diameter were reduced. Epididymal cell height was greatly reduced. The lumen was devoid of spermatozoa. alpha-Chlorohydrin administration inhibited the synthesis of RNA, protein, sialic acid in the testis and accessory sex organs. Total cholesterol of the testis was increased. Adrenal ascorbic acid depletion was conspicuous. alpha-Chlorohydrin anatagonizes the stimulatory action of testosterone in castrated house rats. alpha-Chlorohydrin can be considered as a biologically effective compound for the control of house rat population in human dwellings. It's dose dependent reaction is discussed.

References

Dec 1, 1967·Journal of Reproduction and Fertility·J T Davis, J G Coniglio
May 1, 1974·Contraception·J A Coppola, R J Saldarini
May 1, 1974·Journal of Reproduction and Fertility·B H VickeryJ P Bennett
May 1, 1974·Journal of Reproduction and Fertility·V P DixitH C Jain
Mar 1, 1970·Journal of Reproduction and Fertility·K T KirtonA D Forbes
Jul 1, 1972·Journal of Reproduction and Fertility·U K BanikS Rakhit
Nov 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·S A GunnW A Anderson
Jan 1, 1969·Life Sciences·J A Coppola
Jul 1, 1970·Journal of Reproduction and Fertility·R J Ericsson
Aug 1, 1968·The Journal of Endocrinology·M Rajalakshmi, M R Prasad

❮ Previous
Next ❯

Citations

Jun 15, 1999·International Journal of Andrology·A R Jones, T G Cooper

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.