Inhibition of spinal or hypoglossal motoneurons of the newborn rat by glycine or GABA

The European Journal of Neuroscience
Cristina MarchettiA Nistri

Abstract

The function of GABA or glycine during early postnatal development remains controversial as their action is reported as either excitatory or inhibitory. The present study addressed the question of the functional role of GABA or glycine on rat motoneurons shortly after birth. For this purpose, using in vitro preparations from immature rats (postnatal age, P0-P4 days), we recorded from lumbar spinal motoneurons and hypoglossal motoneurons. All data were obtained under current clamp conditions (recording with potassium methylsulphate containing electrodes) from cells at about -70 mV resting potential. On spinal motoneurons we used the glycinergic and GABAergic recurrent postsysnaptic potential (PSP) mediated by Renshaw cells to assess its impact on excitatory synaptic inputs from dorsal afferent fibres. Despite its depolarizing nature, the recurrent PSP consistently inhibited synaptic excitation of lumbar motoneurons. On hypoglossal motoneurons, exogenously applied GABA or glycine produced depolarization with decreased input resistance. This response was always associated with inhibition of cell firing induced by intracellular current pulses. Even when the membrane potential was repolarized to resting level in the presence of GABA...Continue Reading

References

Aug 1, 1992·Journal of Neurophysiology·S P Schneider, R E Fyffe
Apr 1, 1991·The Journal of Membrane Biology·P H Barry, J W Lynch
Dec 1, 1991·Trends in Neurosciences·E CherubiniY Ben-Ari
Sep 1, 1989·The Journal of Physiology·Y Ben-AriJ L Gaiarsa
Jan 1, 1986·The Journal of Physiology·B P Fulton, K Walton
Mar 22, 1974·Annals of the New York Academy of Sciences·J C Eccles
Jan 1, 1968·Journal of Neurophysiology·R WermanM H Aprison
Jul 1, 1995·Journal of Neurophysiology·B X Gao, L Ziskind-Conhaim
Aug 1, 1995·The Journal of Physiology·F VianaA J Berger
May 1, 1994·The Journal of Physiology·D B ReichlingA B MacDermott
May 1, 1994·The European Journal of Neuroscience·Y HosokawaE Cherubini
Jul 15, 1996·The Journal of Physiology·G ChenA N van den Pol
Nov 19, 1997·Trends in Neurosciences·Y Ben-AriJ L Gaiarsa
May 20, 1998·Journal of Neurophysiology·B X GaoL Ziskind-Conhaim
Nov 18, 1998·Journal of Neurophysiology·J H SingerA J Berger
Sep 14, 1999·Journal of Neurophysiology·J A O'Brien, A J Berger
Jan 19, 2000·Trends in Pharmacological Sciences·J Bormann
Apr 4, 2000·Physiological Reviews·J C ReklingJ L Feldman
May 23, 2000·Journal of Neurochemistry·K Lukasiuk, A Pitkänen
Feb 13, 2001·Brain Research Bulletin·J H Singer, A J Berger
Feb 24, 2001·The European Journal of Neuroscience·R Lape, A Nistri
Oct 1, 1963·The Journal of Physiology·J C ECCLESW D WILLIS

❮ Previous
Next ❯

Citations

Oct 31, 2006·Journal of Computational Neuroscience·Sharmila VenugopalDavid H Terman
Aug 5, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Alessandra CifraAndrea Nistri
Jun 27, 2007·Proceedings of the National Academy of Sciences of the United States of America·Céline Jean-XavierLaurent Vinay
Aug 27, 2005·The Journal of Physiology·Marat MukhtarovPiotr Bregestovski
Jun 1, 2014·The Journal of Physiology·T S AlvaresG D Funk
Feb 4, 2006·The Journal of Physiology·Elina Sharifullina, Andrea Nistri
Mar 9, 2011·Respiratory Physiology & Neurobiology·Albert J Berger
Oct 24, 2007·Brain Research Reviews·Laurent Vinay, Céline Jean-Xavier
Nov 15, 2006·The European Journal of Neuroscience·Nerijus Lamanauskas, Andrea Nistri
Aug 5, 2006·Journal of Neuroscience Methods·Mehrnoush MoghaddasiMichael G Fehlings
Jul 29, 2015·PloS One·Vladimir V DynnikValery P Zinchenko
Oct 20, 2015·Brain Structure & Function·Refik KanjhanMark C Bellingham
Jan 13, 2009·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Cristina RomeiLuca Raiteri
Oct 2, 2002·FEBS Letters·Stéphane Supplisson, Michel J Roux
Sep 24, 2004·Physiological Reviews·Joseph W Lynch
Dec 3, 2004·Journal of Neurophysiology·Huaying XuPeter Wenner
Mar 3, 2006·Journal of Neurophysiology·Joy Y SebeAlbert J Berger
Feb 20, 2020·Journal of Neurophysiology·Morgan M HighlanderSherif M Elbasiouny
Jan 21, 2018·The Journal of Physiology·Lila Buls WollmanRalph F Fregosi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.