PMID: 9193951May 1, 1997Paper

Inhibition of spleen cell proliferative response to mitogens by excretory-secretory antigens of Fasciola hepatica

International Journal for Parasitology
Laura Cervi, Diana T Masih

Abstract

The effect of Fasciola hepatica excretory-secretory antigen (ESA) on the proliferative response of spleen mononuclear (SpM) cells of normal rats to stimulation with mitogens has been examined. When ESA was added to normal SpM cells, there was a decrease in the proliferative response to concanavalin A (Con A) or lipo-polysaccharide (LPS) in a dose-dependent manner. The addition of indomethacin, which blocks prostaglandin synthesis, or N omega-nitro-L-arginine methyl ester (L-NAME) a specific inhibitor of nitric oxide (NO) synthase, had no effect on the ability of ESA to suppress the proliferative response to Con A. However, supplementation of the culture media with catalase, which degrades hydrogen peroxide (H2O2) or superoxide dismutase (SOD) to remove superoxide anion (O2), resulted in a restoration of proliferation to Con A. When LPS was used as mitogenic stimulus no inhibitor added to the culture restored the proliferation. These results suggest that H2O2 and O2- are involved in the suppressor phenomenon induced by ESA in the T-cell proliferative events.

References

Nov 1, 1992·Revista Do Instituto De Medicina Tropical De São Paulo·L A CerviD T Masih
Sep 1, 1992·Experimental Parasitology·G V HillyerG Battisti
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D B SmithG F Mitchell
Jan 1, 1968·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·H Wetterqvist
Oct 1, 1996·Veterinary Immunology and Immunopathology·D T MasihJ M Casado

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Citations

Oct 12, 2001·International Journal for Parasitology·L CerviD T Masih
Oct 9, 1998·Veterinary Immunology and Immunopathology·J PérezA Martínez-Moreno
Sep 19, 2002·Veterinary Parasitology·Emmanuelle MoreauChauvin Alain
Jul 4, 1998·Parasite Immunology·J E Allen, A S MacDonald
May 8, 2010·Veterinary Immunology and Immunopathology·Cristian FalcónLaura Cervi
Apr 24, 2007·Veterinary Immunology and Immunopathology·Marianela C SerradellDiana T Masih
Jul 11, 2013·Veterinary Immunology and Immunopathology·R ZafraA Martínez-Moreno

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