PMID: 2119244Jul 30, 1990Paper

Inhibition of spontaneous and evoked unit activity in the rat medial prefrontal cortex by mesencephalic raphe nuclei

Brain Research
J MantzA M Thierry

Abstract

The rat medial prefrontal cortex (PFC) receives a serotoninergic (5-HT) innervation which originates from the mesencephalic raphe nuclei. In the present study we determined the influence of the 5-HT ascending systems on the spontaneous and evoked activity of PFC neurons in anesthetized rats. Stimulation of the dorsal (DRN) and of the median raphe (MRN) nuclei inhibited the spontaneous activity of 35.0% and 52.8% of the PFC cells tested (mean duration of the inhibition: 75.5 and 82.2 ms, respectively). These inhibitory responses are likely mediated by the 5-HT-containing neurons since they were decreased markedly following selective destruction of ascending 5-HT pathways induced by local injections of 5,7-dihydroxytryptamine. Moreover, the inhibitory effect of MRN stimulation could be blocked by systemic administration of the 5-HT2 receptor antagonists: ketanserin and ritanserin. The effects of MRN stimulation on two types of evoked responses were studied. The excitatory responses of PFC neurons induced by the stimulation of the mediodorsal nucleus of the thalamus (MD) were inhibited by MRN stimulation applied before that of MD. Similarly, the activation of PFC cells induced by a noxious tail pinch was suppressed by a concomitan...Continue Reading

References

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Citations

Dec 21, 1993·European Journal of Pharmacology·A CeciF Borsini
Nov 1, 1992·Progress in Neurobiology·P T FrancisD M Bowen
Dec 15, 2000·Progress in Neurobiology·T M Tzschentke
Jan 6, 2000·Progress in Neurobiology·C M PortasR Ursin
Jan 26, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·G Gobbi, L Janiri
Jun 28, 1992·Annals of the New York Academy of Sciences·K A CunninghamN E Goeders
Aug 13, 2013·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Joanne WallaceSarah E Gartside
Jul 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M D UnderwoodJ J Mann
May 2, 2003·The Journal of Pharmacology and Experimental Therapeutics·Malgorzata Filip, Kathryn A Cunningham
Jun 11, 2011·Journal of Chemical Neuroanatomy·Maria WaselusElisabeth J Van Bockstaele

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