Inhibition of stearoyl-CoA desaturases suppresses follicular help T- and germinal center B- cell responses.

European Journal of Immunology
Young Min SonJie Sun

Abstract

Stearoyl-CoA desaturases (SCD) are endoplasmic reticulum (ER)-associated enzymes that catalyze the synthesis of the monounsaturated fatty acids (MUFAs). As such, SCD play important roles in maintaining the intracellular balance between saturated fatty acid (SFAs) and MUFAs. The roles of SCD in CD4+ T-helper cell responses are currently unexplored. Here, we have found that murine and human follicular helper T (TFH ) cells express higher levels of SCD compared to non-TFH cells. Further, the expression of SCD in TFH cells is dependent on the TFH lineage-specification transcription factor BCL6. We found that the inhibition of SCD impaired TFH cell maintenance and shifted the balance between TFH and follicular regulatory T (TFR ) cells in the spleen. Consequently, SCD inhibition dampened germinal center B-cell responses following influenza immunization. Mechanistically, we found that SCD inhibition led to increased ER stress and enhanced TFH cell apoptosis in vitro and in vivo. These results reveal a possible link between fatty acid metabolism and cellular and humoral responses induced by immunization or potentially, autoimmunity.

References

Dec 11, 2008·American Journal of Physiology. Endocrinology and Metabolism·Chad M Paton, James M Ntambi
Apr 22, 2009·International Immunology·Shin-ichiro KagamiHiroshi Nakajima
Jul 25, 2009·Science·Roza I NurievaChen Dong
May 22, 2010·The Journal of Biological Chemistry·Hiroyuki AriyamaHiroyuki Arai
Sep 29, 2011·Molecular Cancer Research : MCR·Urvashi V RoongtaBrent A Rupnow
Jan 4, 2012·Annals of the New York Academy of Sciences·Harini Sampath, James M Ntambi
Sep 19, 2012·The Journal of Experimental Medicine·Xindong LiuChen Dong
May 2, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christina A von RoemelingJohn A Copland
May 18, 2013·Nature Reviews. Immunology·Stuart G TangyeElissa K Deenick
Aug 6, 2014·Autoimmunity Reviews·Mathilde VersiniYehuda Shoenfeld
Sep 10, 2014·Nature Immunology·Kenneth J OestreichAmy S Weinmann
Nov 1, 2015·The Journal of Clinical Investigation·Masashi MasudaMakoto Miyazaki
Apr 19, 2016·Immunological Reviews·Peter T Sage, Arlene H Sharpe
May 6, 2016·Journal of Lipid Research·Jaeseok Han, Randal J Kaufman
Nov 30, 2016·Molecular Immunology·Markus M XieAlexander L Dent
May 28, 2017·Journal of Leukocyte Biology·Tohti AmetJie Sun
Aug 30, 2017·Journal of Leukocyte Biology·Kathryne E YoungJoseph M Reynolds
Nov 2, 2017·Trends in Endocrinology and Metabolism : TEM·Ahmed M ALJohaniJames M Ntambi
Dec 3, 2017·Science Immunology·Jayendra Kumar KrishnaswamyStephanie C Eisenbarth
Dec 15, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Samad A IbitokouRobin Stephens
Feb 16, 2018·Oncogene·Rita ManciniGennaro Ciliberto
Aug 2, 2018·Frontiers in Immunology·Noémie GensousChristophe Richez
Oct 16, 2018·Frontiers in Immunology·Jayendra Kumar KrishnaswamyAdam Williams
Feb 2, 2019·The Journal of Experimental Medicine·Shenda HouPeter T Sage
May 11, 2019·Frontiers in Immunology·Stefanie K WculekDavid Sancho
Oct 22, 2019·European Journal of Immunology·Andrea CossarizzaArturo Zychlinsky

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Citations

Jan 29, 2021·Mediators of Inflammation·Feiyang CaiGuangjie Chen

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