Inhibition of stimulus-triggered and spontaneous epileptiform activity in rat hippocampal slices by the Aconitum alkaloid mesaconitine

European Journal of Pharmacology
A Ameri

Abstract

The aim of the present study was to investigate if the plant alkaloid, mesaconitine, which has been reported to have antinociceptive effects via stimulation of the noradrenergic system, inhibits epileptiform field potentials. The experiments were performed as extracellular recordings on rat hippocampal slices. Epileptiform activity was induced by omission of Mg2+ from the bathing medium or by addition of bicuculline and stimulus-evoked population bursts were recorded in the CA1 region. Spontaneous epileptiform activity was elicited by perfusing a nominally Mg2+-free bathing medium with high K+ concentration (5 mM). Both stimulus-triggered and spontaneous epileptiform activity was attenuated in a concentration-dependent manner by mesaconitine (30 nM-1 microM). The inhibitory effect was rather variable in appearance when lower concentrations (30 and 100 nM) of mesaconitine were applied. Pretreatment of the slices with the alpha-adrenoceptor antagonist yohimbine (1 microM) prevented the effect of mesaconitine. It is concluded that the inhibitory action of mesaconitine at low concentration is mediated via alpha-adrenoceptors.

References

Apr 1, 1979·European Journal of Pharmacology·H SatoH Hikino
Apr 1, 1986·British Journal of Pharmacology·B Ault, C M Wang
Dec 1, 1987·Naunyn-Schmiedeberg's Archives of Pharmacology·H Bönisch, U Trendelenburg
Jun 11, 1974·Pflügers Archiv : European journal of physiology·H Schmidt, O Schmitt
Dec 10, 1984·Brain Research·A M Campbell, O Holmes
Jan 1, 1980·Annual Review of Pharmacology and Toxicology·W A Catterall
Mar 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·A L MuellerT V Dunwiddie
Dec 1, 1983·Naunyn-Schmiedeberg's Archives of Pharmacology·H BönischB Keller
Feb 15, 1980·The Journal of Comparative Neurology·R LoyR Y Moore
Jan 1, 1994·The American Journal of Chinese Medicine·T IsonoY Omiya
Jun 1, 1994·Trends in Pharmacological Sciences·A DrayA Dickenson
Jan 1, 1996·Neuropharmacology·A AmeriT Peters

❮ Previous
Next ❯

Citations

Jan 28, 2005·International Journal of Legal Medicine·J BeikeH Köhler
Sep 15, 2005·Natural Product Research· Atta-ur-RahmanM Iqbal Choudhary
Jul 15, 2011·Acta Crystallographica. Section E, Structure Reports Online·Yan MuSong-Qing Hu
Sep 23, 2014·The Journal of Pharmacy and Pharmacology·Eric NyirimigaboYanjun Zhang
Mar 26, 2010·Natural Product Reports·Feng-Peng WangXiao-Yu Liu
Aug 24, 2010·Journal of Separation Science·Wenlong LiuShuying Liu
Dec 15, 2019·Clinical and Experimental Pharmacology & Physiology·Lihong ZhaoBingjin Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.