PMID: 6540203Jul 9, 1984Paper

Inhibition of testosterone biosynthesis by ethanol: relation to the pregnenolone-to-testosterone pathway

FEBS Letters
C J ErikssonR Ylikahri

Abstract

The concentrations of metabolites in the pregnenolone in equilibrium testosterone pathway were determined in freeze-stopped testes in control rats and during ethanol intoxication (2 h after injection of 1.5 g ethanol/kg body wt). Ethanol lowered the mean testicular concentrations of testosterone (by 63-74%), androstenedione (49-81%), 17-hydroxyprogesterone (60-76%), progesterone (29-67%) and pregnenolone (12-25%). 4-Methylpyrazole had no effect on the ethanol-induced changes. The present results reveal no inhibition at the 17-hydroxyprogesterone----androstenedione----testosterone steps, but do not exclude inhibition before the step yielding pregnenolone and at the pregnenolone----progesterone----17-hydroxyprogesterone steps.

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Citations

Apr 15, 1986·Biochimica Et Biophysica Acta·S H Andersson, J Sjövall
Apr 15, 1986·Biochimica Et Biophysica Acta·S H AnderssonJ Sjövall
Jan 1, 1990·Journal of Steroid Biochemistry·M HärkönenI Huhtaniemi
Oct 1, 1990·The Journal of Steroid Biochemistry and Molecular Biology·A K OrpanaC J Eriksson
May 5, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S D TadicP K Eagon
Jan 1, 1986·Alcoholism, Clinical and Experimental Research·S AnderssonJ Sjövall
Dec 1, 1994·International Journal of Andrology·J T Pajarinen, P J Karhunen

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