PMID: 8943882Dec 1, 1996Paper

Inhibition of the acute-phase response in vivo by anti-gp130 monoclonal antibodies

British Journal of Haematology
P HarrisonS A Burstein

Abstract

The acute-phase response is believed to be an important systemic defence reaction to inflammation during infection, trauma, injury or neoplasia. Although the interleukin-6 (IL-6) family of cytokines appear to be the major regulators of the acute-phase reaction, the exact biological significance of this process remains unknown. In this study, a panel of monoclonal antibodies (Mabs) was raised against the extracellular domain of human gp130 (the common signal transducing chain of the IL-6 cytokine family) in order to inhibit the biological activity of IL-6-like cytokines in vivo. Mabs designated 4B11 and 2H4 were most effective in the inhibition of the in vitro acute-phase response on hepatoma cells and prevented the IL-6-induced growth inhibition of A375 cells. Administration of the antibodies to dogs at a dosage of 8 mg/kg/d showed that 2H4 was a potent inhibitor of the IL-6-induced (40 micrograms/kg/d) acute-phase response, abrogating IL-6-mediated increments in fibrinogen, C-reactive protein and the platelet count. This antibody, the first described to abrogate the acute-phase response in vivo, may not only permit development of a new anti-inflammatory strategy, but provides an excellent tool for defining the function of acut...Continue Reading

Citations

Feb 7, 1998·Journal of Hepatology·K J SimpsonS L Kunkel
Jun 18, 1999·Gastroenterology Clinics of North America·B E Sands
May 19, 2011·Biochemistry. Biokhimii︠a︡·M N Kostjukova, N N Tupitsyn
May 16, 2013·The American Journal of Pathology·Elena Y SenchenkovaD Neil Granger
Mar 22, 2000·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·J FareedS Haas
Jan 1, 1997·Platelets·S A Burstein

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