Inhibition of the adenosinergic pathway: the indispensable part of oncological therapy in the future

Purinergic Signalling
Yi HuangGuimei Lin

Abstract

In recent years, immunotherapy has produced many unexpected breakthroughs in oncological therapy; however, it still has many deficiencies. For example, the number of patients who are unresponsive to anti-programmed death-ligand 1 (PD-L1), anti-cytotoxic T-like antigen-4 (CTLA4), and anti-programmed death-1 (PD1) therapies cannot be ignored, and the search for an undiscovered immunosuppressive pathway is imminent. Five decades ago, researchers found that activation of the adenosinergic pathway was negatively correlated with prognosis in many cancers. This review describes the entire process of the adenosinergic pathway in the tumor microenvironment and the mechanism of immunosuppression, which promotes tumor metastasis and drug resistance. Additionally, the review explores factors that regulate this pathway, including signaling factors secreted by the tumor microenvironment and certain anti-tumor drugs. Additionally, the combination of adenosinergic pathway inhibitors with chemotherapy, checkpoint blockade therapy, and immune cell-based therapy is summarized. Finally, certain issues regarding treatment via inhibition of this pathway and the use of targeted nanoparticles to reduce adverse reactions in patients are put forward in ...Continue Reading

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Citations

Mar 15, 2020·Purinergic Signalling·Marta Schmidt PfaffenzellerAndréia Machado Cardoso
Feb 13, 2021·Purinergic Signalling·Julia Beatrice de AraújoDébora Tavares de Resende E Silva

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Methods Mentioned

BETA
glycosylation

Clinical Trials Mentioned

NCT02503774
NCT03267589
NCT03454451
NCT03207867
NCT02403193
NCT02655822
NCT02740985
NCT03274479

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