PMID: 7544135May 1, 1995Paper

Inhibition of the angiotensin converting enzyme by perindoprilat and release of nitric oxide

American Journal of Hypertension
B DestaC M Boulanger

Abstract

Experiments were designed to investigate the mechanism underlying the endothelium-dependent relaxations to perindoprilat, a converting enzyme inhibitor, in canine coronary arteries previously exposed to bradykinin. Rings suspended in organ chambers were exposed to bradykinin for 3 min and washed extensively for 150 min. In rings previously exposed to the peptide, bradykinin induced relaxations which were augmented in the presence of perindoprilat; this response was not affected by indomethacin, but nitro-L-arginine induced a rightward shift of the relaxation to the peptide without affecting its maximal effect. In canine coronary arteries previously exposed to the peptide, perindoprilat caused endothelium-dependent relaxations (IC50 = 7.83), which had been observed previously at concentrations where the converting enzyme inhibitor did not augment the response to bradykinin. Carboxypeptidase B, but not aprotinin, impaired the relaxation to perindoprilat, suggesting a contribution of bradykinin. The relaxation to perindoprilat was not affected by the B1 antagonist Leu8-des-Arg9-bradykinin. However, the bradykinin B2 antagonist HOE-140 displayed a noncompetitive antagonism against the response to perindoprilat. The response to the ...Continue Reading

Citations

Aug 1, 1996·Clinical and Experimental Pharmacology & Physiology·P M Vanhoutte
Jun 23, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yasuhiro TarutaniMinoru Horie
Oct 1, 1996·Journal of the American College of Cardiology·C Rosendorff

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