Inhibition of the Continuum of Radiation-Induced Normal Tissue Injury by a Redox-Active Mn Porphyrin

Radiation Research
Samuel R BirerKathleen A Ashcraft

Abstract

Normal tissue damage after head and neck radiotherapy involves a continuum of pathologic events to the mucosa, tongue and salivary glands. We examined the radioprotective effects of MnBuOE, a redox-active manganese porphyrin, at three stages of normal tissue damage: immediate (leukocyte endothelial cell [L/E] interactions), early (mucositis) and late (xerostomia and fibrosis) after treatment. In this study, mice received 0 or 9 Gy irradiation to the oral cavity and salivary glands ± MnBuOE treatment. Changes in leukocyte-endothelial cell interactions were measured 24 h postirradiation. At 11 days postirradiation, mucositis was assessed with a cathepsin-sensitive near-infrared optical probe. Stimulated saliva production was quantified at 11 weeks postirradiation. Finally, histological analyses were conducted to assess the extent of long-term effects in salivary glands at 12 weeks postirradiation. MnBuOE reduced oral mucositis, xerostomia and salivary gland fibrosis after irradiation. Additionally, although we have previously shown that MnBuOE does not interfere with tumor control at high doses when administered with radiation alone, most head and neck cancer patients will be treated with the combinations of radiotherapy and cisp...Continue Reading

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Citations

Nov 9, 2017·Antioxidants & Redox Signaling·Xiaofei ChenCristina M Furdui
Aug 11, 2020·Oxidative Medicine and Cellular Longevity·Gan Huang, Shu-Ting Pan
Apr 6, 2021·Oxidative Medicine and Cellular Longevity·Ines Batinic-HaberleAngeles Alvarez Secord

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Methods Mentioned

BETA
xenograft
X-ray
Fluorescence

Clinical Trials Mentioned

NCT02990468

Software Mentioned

GraphPad Prism
Zeiss
MATLAB
AxioVision
Zen Imaging
TrueQuant

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