Inhibition of the development of myringosclerosis by local administration of fenspiride, an anti-inflammatory drug

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
C Mattsson, S Hellström

Abstract

Earlier studies have revealed a relationship between the development of myringosclerosis and oxygen-derived free radicals. The latter can be blocked by the anti-inflammatory drug fenspiride. The present study was undertaken to test the ability of fenspiride to prevent myringosclerosis from developing during healing of the tympanic membrane. Myringotomized rats were treated with either topical applications or intraperitoneal injections of fenspiride for 12 days, after which the tympanic membranes were examined by otomicroscopy and studied histologically by light microscopy. Topically applied fenspiride was found to inhibit the development of sclerotic lesions, whereas intraperitoneal injections were ineffective.

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Citations

May 9, 2002·International Journal of Pediatric Otorhinolaryngology·Cengiz OzcanIsmail Cinel
Apr 17, 2002·International Journal of Pediatric Otorhinolaryngology·Marie Forséni Flodin, Malou Hultcrantz
Feb 26, 2011·The Journal of Laryngology and Otology·V KahyaO Gedikli
Jun 15, 2011·International Journal of Pediatric Otorhinolaryngology·Ersoy DoganEnis Alpin Güneri
Apr 29, 2009·Auris, Nasus, Larynx·Hayrettin Cengiz AlpaySinasi Yalcin
Jun 5, 2007·International Journal of Pediatric Otorhinolaryngology·Jae-Jun SongSeok-Won Park
Sep 15, 2005·International Journal of Pediatric Otorhinolaryngology·Giedre RaustyteJens Thomsen
Feb 1, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Cengiz OzcanIsmail Cinel
May 30, 2015·International Journal of Pediatric Otorhinolaryngology·Oğuz Kadir EğilmezMuhammet Tekin
Jan 15, 2015·International Journal of Pediatric Otorhinolaryngology·Evin Das SahinAbdulvahap Akyigit
Nov 28, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Vefa KinisIsmail Topcu
Aug 9, 2016·International Journal of Pediatric Otorhinolaryngology·Numan KoktenErdem Yesilada
Nov 8, 2001·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·M Forséni Flodin
Apr 9, 2002·Acta Oto-laryngologica·Cecilia MattssonSten Hellström
Apr 28, 2006·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·K Cagdas KazikdasKazim Onal
Apr 5, 2008·The Laryngoscope·Ibrahim OzcanCandan Ozogul
Aug 16, 2017·The Journal of Laryngology and Otology·Y ZhangA Liu
Jul 13, 2021·The International Journal of Biochemistry & Cell Biology·Aiste DobrovolskaiteOtto Phanstiel

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