Inhibition of the essential oil from Chenopodium ambrosioides L. and α-terpinene on the NorA efflux-pump of Staphylococcus aureus

Food Chemistry
Cícera Datiane de Morais Oliveira-TintinoTeresinha Gonçalves da Silva

Abstract

This study was carried out to test the essential oil from C. ambrosioides leaves and its main constituent, α-Terpinene, in an antibacterial activity assay. As well, it was evaluated ability reduce resistance to norfloxacin and ethidium bromide was compared the Staphylococcus aureus 1199B whith 1199 wild type strain. The MIC of the C. ambrosioides essential oil and α-Terpinene were determined by microdilution method. The MIC of the essential oil and α-Terpinene presented a value ≥ 1024 μg/mL. However, when associated with antibacterials, the essential oil from C. ambrosioides leaves significantly reduced the MIC of antibiotics and ethidium bromide, characterizing an efflux pump inhibition. The C. ambrosioides essential oil, despite having no direct antibacterial activity against the S. aureus 1199B strain, showed a potentiating action when associated with antibacterial agents, this being attributed to an inhibition of efflux pumps.

Citations

Mar 27, 2020·BMC Complementary Medicine and Therapies·Shuzhen XiaoYing Zhang
Jan 1, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Marina Micaele Rodrigues SiqueiraHenrique Douglas Melo Coutinho
Feb 9, 2021·Critical Reviews in Food Science and Nutrition·Alberto Gonçalves EvangelistaFernando Bittencourt Luciano
Jul 6, 2020·Current Topics in Medicinal Chemistry·Kadja Luana Chagas MonteiroFrancisco Jaime B Mendonça Junior
May 5, 2021·Archives of Microbiology·Roger Henrique Sousa da CostaIrwin Rose Alencar de Menezes
May 22, 2021·Evolutionary Bioinformatics Online·Shun-Kai YangKok-Song Lai
Jul 17, 2021·Current Microbiology·Ana Carolina Justino de AraújoHenrique Douglas Melo Coutinho
Aug 10, 2021·Frontiers in Pharmacology·Tushar KhareVinay Kumar
Aug 26, 2021·Current Microbiology·Maria Anndressa Alves AgrelesIsabella Macário Ferro Cavalcanti
Mar 31, 2021·Current Drug Metabolism·Saulo Relison, Pedro S Pereira

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