Abstract
This study was carried out to test the essential oil from C. ambrosioides leaves and its main constituent, α-Terpinene, in an antibacterial activity assay. As well, it was evaluated ability reduce resistance to norfloxacin and ethidium bromide was compared the Staphylococcus aureus 1199B whith 1199 wild type strain. The MIC of the C. ambrosioides essential oil and α-Terpinene were determined by microdilution method. The MIC of the essential oil and α-Terpinene presented a value ≥ 1024 μg/mL. However, when associated with antibacterials, the essential oil from C. ambrosioides leaves significantly reduced the MIC of antibiotics and ethidium bromide, characterizing an efflux pump inhibition. The C. ambrosioides essential oil, despite having no direct antibacterial activity against the S. aureus 1199B strain, showed a potentiating action when associated with antibacterial agents, this being attributed to an inhibition of efflux pumps.
Citations
May 16, 2020·Antibiotics·Ray S AlmeidaHenrique D M Coutinho
Nov 27, 2019·Antibiotics·Xiao-Yu SongGary Strobel
Mar 27, 2020·BMC Complementary Medicine and Therapies·Shuzhen XiaoYing Zhang
Jan 1, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Marina Micaele Rodrigues SiqueiraHenrique Douglas Melo Coutinho
Feb 9, 2021·Critical Reviews in Food Science and Nutrition·Alberto Gonçalves EvangelistaFernando Bittencourt Luciano
Jul 6, 2020·Current Topics in Medicinal Chemistry·Kadja Luana Chagas MonteiroFrancisco Jaime B Mendonça Junior
Apr 16, 2021·International Journal of Microbiology·Eshetu Gadisa, Hydar Usman
May 5, 2021·Archives of Microbiology·Roger Henrique Sousa da CostaIrwin Rose Alencar de Menezes
May 22, 2021·Evolutionary Bioinformatics Online·Shun-Kai YangKok-Song Lai
Jun 1, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Janaína Esmeraldo RochaHenrique Douglas Melo Coutinho
Jul 17, 2021·Current Microbiology·Ana Carolina Justino de AraújoHenrique Douglas Melo Coutinho
Aug 4, 2021·International Journal of Biological Macromolecules·Fei ZengJinao Duan
Aug 10, 2021·Frontiers in Pharmacology·Tushar KhareVinay Kumar
Aug 26, 2021·Current Microbiology·Maria Anndressa Alves AgrelesIsabella Macário Ferro Cavalcanti
Aug 5, 2020·Current Drug Metabolism·Priscilla R FreitasHenrique D M Coutinho
Jan 6, 2021·Current Drug Metabolism·Ana C J de AraújoHenrique D M Coutinho
Mar 31, 2021·Current Drug Metabolism·Saulo Relison, Pedro S Pereira
Dec 24, 2021·Archives of Microbiology·Janaína Esmeraldo RochaHenrique Douglas Melo Coutinho