PMID: 2486053Jan 1, 1989Paper

Inhibition of the induction of contact hypersensitivity by an epithelial cell-derived interleukin-1 inhibitor

The Australasian Journal of Dermatology
L J WalshG J Seymour

Abstract

Interleukin-1 (IL-1) is the central hormone of acute inflammation. Previous studies have demonstrated that an Interleukin-1 inhibitor (ILS) derived from human gingival epithelial cell cultures abrogates the effect of IL-1 on human Langerhans cells and murine thymocytes in vitro. The present study investigated the effect of ILS on the induction and elicitation of contact hypersensitivity (CHS) to 2,4-dinitro-1-fluorobenzene (DNFB). Systemic administration of ILS 6 days prior to sensitisation significantly blocked the induction of CHS to DNFB in Balb/c mice. In addition, i.v. injection of ILS 24 or 48 hours prior to the elicitation of CHS produced a reduction in ear swelling, but the suppressive effect was less profound than when ILS was administered prior to sensitisation. Thus, ILS production by epithelial cells is a possible mechanism for the down-regulation of cutaneous immune responses.

References

Oct 1, 1985·The Journal of Clinical Investigation·L C GahringR A Daynes
Jan 1, 1988·Journal of Oral Pathology·L J WalshR N Powell
Jan 1, 1988·The Journal of Investigative Dermatology·L J Walsh, G J Seymour
Aug 1, 1986·The Journal of Investigative Dermatology·T SchwarzT A Luger
Jan 1, 1984·Reviews of Infectious Diseases·C A Dinarello
Jun 1, 1984·The Journal of Investigative Dermatology·D N SauderV B Morhenn

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Citations

Oct 1, 1990·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·L J WalshG J Seymour

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