Severe acute respiratory syndrome coronavirus (SARS-CoV) is a highly pathogenic emergent virus which replicates in cells that can express ABH histo-blood group antigens. The heavily glycosylated SARS-CoV spike (S) protein binds to angiotensin-converting enzyme 2 which serves as a cellular receptor. Epidemiological analysis of a hospital outbreak in Hong Kong revealed that blood group O was associated with a low risk of infection. In this study, we used a cellular model of adhesion to investigate whether natural antibodies of the ABO system could block the S protein and angiotensin-converting enzyme 2 interaction. To this aim, a C-terminally EGFP-tagged S protein was expressed in chinese hamster ovary cells cotransfected with an alpha1,2-fucosyltransferase and an A-transferase in order to coexpress the S glycoprotein ectodomain and the A antigen at the cell surface. We observed that the S protein/angiotensin-converting enzyme 2-dependent adhesion of these cells to an angiotensin-converting enzyme 2 expressing cell line was specifically inhibited by either a monoclonal or human natural anti-A antibodies, indicating that these antibodies may block the interaction between the virus and its receptor, thereby providing protection. In...Continue Reading
Antibody to histo-blood group A antigen neutralizes HIV produced by lymphocytes from blood group A donors but not from blood group B or O donors
Recognition of the blood group H type 2 trisaccharide epitope by 28 monoclonal antibodies and three lectins
Comparison of the three rat GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferases FTA, FTB and FTC
ABH and Lewis histo-blood group antigens, a model for the meaning of oligosaccharide diversity in the face of a changing world
Expression of ABO or related antigenic carbohydrates on viral envelopes leads to neutralization in the presence of serum containing specific natural antibodies and complement.
Cloning of a rat gene encoding the histo-blood group A enzyme. Tissue expression of the gene and of the A and B antigens
Natural antibodies and complement are endogenous adjuvants for vaccine-induced CD8+ T-cell responses
A 193-amino acid fragment of the SARS coronavirus S protein efficiently binds angiotensin-converting enzyme 2.
Amino acids 270 to 510 of the severe acute respiratory syndrome coronavirus spike protein are required for interaction with receptor
A novel cell-based binding assay system reconstituting interaction between SARS-CoV S protein and its cellular receptor
HIV-1 incorporates ABO histo-blood group antigens that sensitize virions to complement-mediated inactivation.
The SARS coronavirus S glycoprotein receptor binding domain: fine mapping and functional characterization
Animal origins of the severe acute respiratory syndrome coronavirus: insight from ACE2-S-protein interactions.
Virus recognition by specific natural antibodies and complement results in MHC I cross-presentation.
Plant lectins are potent inhibitors of coronaviruses by interfering with two targets in the viral replication cycle
Specific asparagine-linked glycosylation sites are critical for DC-SIGN- and L-SIGN-mediated severe acute respiratory syndrome coronavirus entry
Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen.
Recent Insight into SARS-CoV2 Immunopathology and Rationale for Potential Treatment and Preventive Strategies in COVID-19
The first, holistic immunological model of COVID-19: implications for prevention, diagnosis, and public health measures
The effect of abo and rh blood group antigens on admission to intensive care unit and mortality in patients with COVID-19 infection
Harnessing the natural anti-glycan immune response to limit the transmission of enveloped viruses such as SARS-CoV-2
Postmortem examination of COVID-19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings in lungs and other organs suggesting vascular dysfunction.
Human Natural Antibodies to Mammalian Carbohydrate Antigens as Unsung Heroes Protecting against Past, Present, and Future Viral Infections
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and coronavirus disease 19 (COVID-19) - anatomic pathology perspective on current knowledge
COVID-19 and Individual Genetic Susceptibility/Receptivity: Role of ACE1/ACE2 Genes, Immunity, Inflammation and Coagulation. Might the Double X-chromosome in Females Be Protective against SARS-CoV-2 Compared to the Single X-Chromosome in Males?
Anti-A isohaemagglutinin titres and SARS-CoV-2 neutralization: implications for children and convalescent plasma selection
Host Synthesized Carbohydrate Antigens on Viral Glycoproteins as "Achilles' Heel" of Viruses Contributing to Anti-Viral Immune Protection
Immunologic aspects of characteristics, diagnosis, and treatment of coronavirus disease 2019 (COVID-19)
The association of ABO blood group with indices of disease severity and multiorgan dysfunction in COVID-19.
Clinical predictors of donor antibody titre and correlation with recipient antibody response in a COVID-19 convalescent plasma clinical trial.
The central role of the nasal microenvironment in the transmission, modulation, and clinical progression of SARS-CoV-2 infection.
Naturally Occurring Animal Coronaviruses as Models for Studying Highly Pathogenic Human Coronaviral Disease.
Relationship Between the ABO Blood Group and the Coronavirus Disease 2019 (COVID-19) Susceptibility.
The histo-blood group antigens of the host cell may determine the binding of different viruses such as SARS-CoV-2.
Adhesion Molecules in Health and Disease
Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.