Inhibition of the late phase reaction to anti-IgE by previous mast cell activation with compound 48/80

Allergy
R Grönneberg

Abstract

The concept of an obligate association between mast cell activation and development of a late phase reaction (LPR) to various agents in human skin was further elucidated. Skin sites were treated four times at 24 h intervals with non-LPR-inducing doses of the histamine liberator compound 48/80 in 10 volunteers. The previously compound 48/80-challenged sites responded with an approximately 40% attenuated early response (P less than 0.01) and a 70% reduction of the LPR (P less than 0.001) to subsequently injected anti-IgE as compared with simultaneous reactions at control sites. The data suggest that mediators from the cutaneous mast cells are necessary for the final expression of an LPR.

References

Dec 1, 1976·Archives of Disease in Childhood·J O Warner
Oct 1, 1977·The Journal of Allergy and Clinical Immunology·W ShaikhJ Dolovich
Aug 1, 1976·The Journal of Clinical Investigation·G O SolleyA L Schroeter
Oct 1, 1967·The Journal of Allergy·G R GreenE A Hildreth
May 1, 1983·The Journal of Allergy and Clinical Immunology·S TingR Lavker

Citations

May 16, 2002·Fertility and Sterility·Yukiko OkamotoMizuo Miyazaki
Apr 25, 2008·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·I Leonard BernsteinAmerican College of Allergy, Asthma and Immunology
Jun 25, 2014·American Journal of Veterinary Research·Michelle C WoodwardCherie M Pucheu-Haston

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