Inhibition of the Notch1 pathway induces peripartum cardiomyopathy.

Journal of Cellular and Molecular Medicine
Rong-Rong ZhuXue-Liang Zhou

Abstract

Increased expression and activity of cardiac and circulating cathepsin D and soluble fms-like tyrosine kinase-1 (sFlt-1) have been demonstrated to induce and promote peripartum cardiomyopathy (PPCM) via promoting cleavage of 23-kD prolactin (PRL) to 16-kD PRL and neutralizing vascular endothelial growth factor (VEGF), respectively. We hypothesized that activation of Hes1 is proposed to suppress cathepsin D via activating Stat3, leading to alleviated development of PPCM. In the present study, we aimed to investigate the role of Notch1/Hes1 pathway in PPCM. Pregnant mice between prenatal 3 days and postpartum 3 weeks were fed with LY-411575 (a notch inhibitor, 10 mg/kg/d). Ventricular function and pathology were evaluated by echocardiography and histological analysis. Western blotting analysis was used to examine the expression at the protein level. The results found that inhibition of Notch1 significantly promoted postpartum ventricular dilatation, myocardial hypertrophy and myocardial interstitial fibrosis and suppressed myocardial angiogenesis. Western blotting analysis showed that inhibition of Notch1 markedly increased cathepsin D and sFlt-1, reduced Hes1, phosphorylated Stat3 (p-Stat3), VEGFA and PDGFB, and promoted cleavag...Continue Reading

References

Feb 10, 2007·Cell·Denise Hilfiker-KleinerHelmut Drexler
Apr 27, 2013·The Journal of Clinical Investigation·Julie HalkeinIngrid Struman
Jan 23, 2014·Cardiovascular Research·Melanie Ricke-HochDenise Hilfiker-Kleiner
Feb 13, 2014·Cardiovascular Research·Arash HaghikiaDenise Hilfiker-Kleiner
Nov 29, 2014·Cell Biochemistry and Function·Xue-liang ZhouJi-chun Liu
Sep 18, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ryojun NakajimaToshio Harigaya
Mar 14, 2016·JACC. Heart Failure·Julie DampUNKNOWN IPAC Investigators
Nov 20, 2016·Journal of Cellular Physiology·Dan ZhaoYunfeng Lin
May 9, 2018·Journal of Cellular Biochemistry·Xue-Liang ZhouJi-Chun Liu
May 17, 2018·Herz·T KoenigJ Bauersachs
May 29, 2018·Journal of Cellular and Molecular Medicine·Xue-Liang ZhouJi-Chun Liu
Aug 21, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Julie A DampUri Elkayam
Oct 1, 2018·Current Treatment Options in Cardiovascular Medicine·Abigail KhanShimoli Shah
Apr 3, 2019·Néphrologie & thérapeutique·Henri BoulangerEmmanuel Dupuis

❮ Previous
Next ❯

Citations

Apr 6, 2021·Journal of Orthopaedic Translation·Jianhai ChenPeng Zhang
Jul 6, 2021·Frontiers in Cardiovascular Medicine·Graham ChakafanaKaren Sliwa

❮ Previous
Next ❯

Methods Mentioned

BETA
protein assay
ELISA
PCR

Software Mentioned

ImageQuant
SPSS

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

© 2022 Meta ULC. All rights reserved