PMID: 9529074Apr 7, 1998Paper

Inhibition of the production of anti-OspA borreliacidal antibody with T cells from hamsters vaccinated against Borrelia burgdorferi

Infection and Immunity
J R JensenRonald F Schell

Abstract

The serious morbidity associated with Lyme borreliosis has focused considerable effort on the development of a comprehensive vaccine for protection against infection with Borrelia burgdorferi. Induction of borreliacidal antibody by vaccination or infection has been shown to correlate with protection of humans and animals against infection with the Lyme spirochete. In this report, we showed that high levels of borreliacidal antibody (titer of 1,280) were produced in vitro when T and B cells from hamsters 14 days after vaccination were incubated with macrophages and B. burgdorferi. By contrast, T and B cells from hamsters 7 or 21 days after vaccination failed to initiate production of borreliacidal activity. Furthermore, the T cells from hamsters 7 or 21 days after vaccination inhibited the in vitro production of borreliacidal antibody when cocultured with T and B cells obtained from hamsters 14 days after vaccination. When cell-free supernatants from the suspensions of T and B cells from hamsters 14 days after vaccination were absorbed with recombinant OspA, they lost nearly all borreliacidal activity. The removal of anti-OspA antibody resulted in a decrease in borreliacidal titer from 1,280 to less than 4. These results demonst...Continue Reading

References

Nov 22, 1990·The New England Journal of Medicine·E L LogigianA C Steere
Sep 1, 1988·The Journal of Infectious Diseases·J C Garcia-MoncoJ L Benach
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Sep 11, 1997·The New England Journal of Medicine·S E SchutzerP K Coyle

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Citations

Jan 13, 2004·Clinical and Diagnostic Laboratory Immunology·Erik L MunsonRonald F Schell
Oct 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Victoria A BlahoCharles R Brown
Jun 27, 2008·Clinical and Vaccine Immunology : CVI·Nicholas J KotloskiRonald F Schell

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