PMID: 1164590Jul 1, 1975

Inhibition of the pulmonary inactivation of prostaglandins in vivo by di-4-phloretin phosphate

British Journal of Pharmacology
D J Crutchley, P J Piper


1 Inactivation of prostaglandin E2 in the pulmonary circulation of rabbits in vivo was measured by comparing the hypotensive effects of doses given intravenously and intra-arterially. 2 Di-4-phloretin phosphate (DPP) 25-100 mug kg-1 min-1 inhibited the inactivation of prostaglandin E2 in the pulmonary circulation. 3 These doses of DPP caused a marked shift to the left of the dose-response curve to prostaglandin E2 given intravenously but did not affect the dose-response curve to prostaglandin E2 given intra-arterially. 4 Inhibition of pulmonary inactivation of prostaglandins E2 and F2alpha caused marked potentiation of their gastrointestinal effects. 5 At these doses antagonism of the hypotensive action of prostaglandin E2 by DPP was seldom seen but the gastrointestinal effect of prostaglandin F2alpha was sometimes antagonized. 6 After treatment with DPP 100 mug kg-1 min-1, high doses of prostaglandin were sometimes lethal.


Aug 15, 1977·European Journal of Pharmacology·D J CrutchleyJ P Seale
Oct 1, 1976·Prostaglandins·H S Hansen
Jan 1, 1977·Pharmacology & Therapeutics. Part B: General & Systematic Pharmacology·P J Piper
Feb 1, 1978·British Journal of Pharmacology·Y S BakhleB J Whittle
Feb 1, 1978·Acta Physiologica Scandinavica·T WibergK M Gautvik


Apr 1, 1975·British Journal of Pharmacology·J R Bedwani, P B Marley
Oct 1, 1974·British Journal of Pharmacology·D J Crutchley, P J Piper
Jan 1, 1969·Physiological Reviews·E W HORTON
Jul 1, 1970·British Journal of Pharmacology·K E EakinsJ D Miller
Oct 1, 1973·Japanese Circulation Journal·E UedaY Yamamura
Feb 1, 1969·British Journal of Pharmacology·J R Vane
Jun 1, 1972·British Journal of Pharmacology·V A Alabaster, Y S Bakhle
Jun 1, 1972·Prostaglandins·M J SilverJ J Kocsis
Feb 1, 1973·British Journal of Pharmacology·V A Alabaster, Y S Bakhle
Feb 14, 1970·Nature·P J PiperJ H Wyllie
Dec 1, 1968·The Biochemical Journal·J W RyanJ M Stewart
Jun 1, 1967·British Journal of Pharmacology and Chemotherapy·S H Ferreira, J R Vane
May 1, 1963·Acta Physiologica Scandinavica·E ANGGARD, S BERGSTROM
Aug 1, 1963·British Journal of Pharmacology and Chemotherapy·E W HORTON, I H MAIN

Related Concepts

Depression, Chemical
Diastolic Blood Pressure
Phosphate Measurement
Prostaglandin E2 Measurement
Metabolic Inhibition
Prostaglandin cardiac therapy preparations
Pulmonary Circulation

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