Inhibition of the Receptor for Advanced Glycation End-Products (RAGE) Attenuates Neuroinflammation While Sensitizing Cortical Neurons Towards Death in Experimental Subarachnoid Hemorrhage

Molecular Neurobiology
Hua LiChunhua Hang

Abstract

Subarachnoid hemorrhage (SAH) is a threatening and devastating neurological insult with high mortality and morbidity rates. Despite considerable efforts, the underlying pathophysiological mechanisms are still poorly understood. The receptor for advanced glycation end products (RAGE) is a multiligand receptor that has been implicated in various pathological conditions. We previously showed that RAGE was upregulated and may be involved in pathophysiology of SAH. In the current study, we investigated its potential role in SAH. We found that the upregulation of RAGE after SAH was NF-κB-dependent positive feedback regulation. Further, pharmacological inhibition of RAGE attenuated neuroinflammation, indicating a possible contributive role of RAGE in inflammation-associated brain injury after SAH. Conversely, however, inhibition of RAGE sensitized neurons, exacerbating cell death, which correlated with augmented apoptosis and diminished autophagy, suggesting that activation of RAGE may protect against SAH-induced neuronal injury. Furthermore, we demonstrate that inhibition of RAGE significantly reduced brain edema and improved neurological function at day 1 but not at day 3 post-SAH. Taken together, these results suggest that RAGE exe...Continue Reading

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Citations

Oct 9, 2016·Neurochemical Research·Hua LiChun-Hua Hang
May 5, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Erik G HaymanJ Marc Simard
Apr 11, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Jing-Peng LiuChun-Hua Hang
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Jan 28, 2017·International Journal of Inflammation·Manoj Banjara, Chaitali Ghosh
Apr 17, 2020·International Journal of Molecular Sciences·Sajjad MuhammadDaniel Hänggi

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Methods Mentioned

BETA
ELISA
Enzyme-Linked Immunosorbent Assay

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