PMID: 3756519Sep 24, 1986Paper

Inhibition of the responses of neurons in the rat spinal cord to noxious skin heating by stimulation in midbrain periaqueductal gray or lateral reticular formation

Brain Research
E Carstens, L R Watkins

Abstract

Single units responsive to noxious heating of glabrous hindfoot skin were recorded in the lumbar spinal cord of rats anesthetized with sodium pentobarbital. Unit responses to heat stimuli (e.g. 50 degrees C, 10 s) delivered at 2-min intervals were stable and were markedly suppressed during stimulation (100-ms pulse trains at 100 Hz, 3/s, 25-400 microA) in the midbrain periaqueductal gray (PAG) or lateral reticular formation (LRF). Inhibition did not appear to outlast the midbrain stimulation period. By systematically varying the position of an array of 3 or 5 stimulating electrodes, we observed that stimulation in PAG and subjacent tegmental areas, as well as in widespread regions of the LRF bilaterally, suppressed unit responses to noxious skin heating. The degree of suppression of unit responses increased with graded increases in PAG or LRF stimulation intensity. LRF appeared to be more efficacious than PAG stimulation, based on lower currents at threshold, as well as on significantly greater slopes in current-inhibition plots for LRF compared to PAG stimulation. Unit responses increased linearly with graded increases in stimulus temperature from 42 to 54 degrees C. Slopes of temperature-response lines were reduced during PAG...Continue Reading

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Citations

Jun 21, 1988·Brain Research·F P Zemlan, M M Behbehani
Feb 1, 1992·Electroencephalography and Clinical Neurophysiology·K ShimojiT Hokari
Aug 1, 1995·Progress in Neurobiology·M M Behbehani
Jan 1, 1991·Neuroscience·S T Meller, B J Dennis
Sep 1, 2004·American Journal of Veterinary Research·B Duncan X Lascelles, Sheilah A Robertson
Apr 3, 2004·Journal of Veterinary Internal Medicine·B Duncan X Lascelles, Sheilah A Robertson
Feb 1, 1997·Journal of Neurophysiology·D K Douglass, E Carstens
Apr 29, 2021·The European Journal of Neuroscience·Karina Genaro, Wiliam A Prado

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