PMID: 7018565May 12, 1981Paper

Inhibition of the RTEM beta-lactamase from Escherichia coli. Interaction of enzyme with derivatives of olivanic acid

Biochemistry
R L Charnas, J R Knowles

Abstract

The interaction of the RTEM beta-lactamase with two derivatives of olivanic acid has been studied. The compound MM22382 (1) behaves simply as a good substrate for the enzyme and is a relatively ineffective inhibitor. In contrast, the sulfate ester MM13902 (2) is a poor substrate and an excellent inhibitor of the enzyme. The inhibition derives from a branching of the normal hydrolytic pathway of the enzyme. At long times, all the catalytic activity of the enzyme returns. Free sulfate ion is not produced during the interaction with the enzyme, which rules out a mechanistic pathway involving beta elimination between C-6 and C-8. The validity of a number of alternative schemes is assessed.

References

Sep 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R F Pratt, M J Loosemore
Mar 22, 1979·Nature·S J Cartwright, A F Coulson
Jan 1, 1979·The Biochemical Journal·V Knott-HunzikerS G Waley
Aug 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J G Sutcliffe
Jun 1, 1976·The Journal of Antimicrobial Chemotherapy·R B Sykes, M Matthew
Jan 6, 1975·Biochemical and Biophysical Research Communications·A Samuni, N Citri
Apr 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·N CitriN Zyk
Sep 1, 1977·The Journal of Antibiotics·K MaedaH Umezawa
Jun 1, 1976·The Journal of Antibiotics·A G BrownG N Rolinson
May 16, 1980·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J FisherJ R Knowles
Mar 1, 1980·The Journal of Antibiotics·K OkamuraT Ishikura

❮ Previous
Next ❯

Citations

Jul 4, 2012·Proceedings of the National Academy of Sciences of the United States of America·David E EhmannStewart L Fisher
Oct 15, 1984·European Journal of Biochemistry·N CitriN Zyk
Aug 24, 2011·Antimicrobial Agents and Chemotherapy·Krisztina M Papp-WallaceRobert A Bonomo
May 30, 2013·Antimicrobial Agents and Chemotherapy·Toni L LamoureauxSergei B Vakulenko
Jan 1, 1984·Antimicrobial Agents and Chemotherapy·T HashizumeT Sawai
Mar 1, 1984·Antimicrobial Agents and Chemotherapy·A YamaguchiT Sawai
May 1, 1985·Antimicrobial Agents and Chemotherapy·K Murakami, T Yoshida
Sep 1, 1986·Antimicrobial Agents and Chemotherapy·K MurakamiT Yoshida
Jan 13, 2010·Clinical Microbiology Reviews·Sarah M Drawz, Robert A Bonomo
Oct 6, 2004·Expert Opinion on Investigational Drugs·Nafsika H Georgopapadakou
Nov 3, 2015·Analytical Biochemistry·Qiongjing Zou, Kun-Lin Yang
Jan 25, 1982·FEBS Letters·S J Cartwright, A L Fink
Apr 2, 2002·Expert Opinion on Investigational Drugs·Giovanni BonfiglioGiuseppe Nicoletti
Jan 11, 2011·Journal of Molecular Biology·Kyle D SchneiderDavid A Leonard
Nov 19, 1985·Biochemistry·R Bicknell, S G Waley
May 10, 2013·The Journal of Biological Chemistry·Krisztina M Papp-WallaceMichiyoshi Nukaga
Sep 14, 2019·Antibiotics·Krisztina M Papp-WallaceFocco van den Akker
Sep 22, 2019·Scientific Reports·Christopher T LohansChristopher J Schofield
Oct 1, 1983·Medicinal Research Reviews·S J Cartwright, S G Waley
Aug 11, 2001·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Malcolm G. P. Page
Aug 14, 1987·Biochemical and Biophysical Research Communications·J E Baldwin, D W Parker

❮ Previous
Next ❯

Related Concepts

Related Feeds

Beta-lactamase Inhibitors

Beta-lactamase inhibitors are a class of antibiotics that inhibit beta-lactamases, a family of enzymes involved in bacterial resistance to beta-lactam antibiotics. Here is the latest research.

Beta-lactamase Inhibitors (ASM)

Beta-lactamase inhibitors are a class of antibiotics that inhibit beta-lactamases, a family of enzymes involved in bacterial resistance to beta-lactam antibiotics. Here is the latest research.