Inhibition of the vascular actions of IgG aggregates by BN 52021, a highly specific antagonist of paf-acether

M Sánchez-CrespoP Braquet


The effect of BN 52021, a selective antagonist of paf-acether (Braquet GB patent 8, 418, 424 July 19, 1984), was studied in normotensive rats challenged with different doses of paf-acether. Sudden death was observed in animals receiving an i.v. dose of 10 micrograms/kg of paf-acether and this was prevented by prior treatment with BN 52021 (5 mg/kg, i.v.). Animals receiving 2.5 micrograms/kg of paf-acether had a fall of mean arterial pressure of 92.5 +/- 4.7 mmHg which recovered to the prechallenge level 20.5 +/- 0.2 min thereafter. Previous treatment with BN 52021 (5 mg/kg, i.v.) reduced the mean arterial pressure fall to 47 +/- 0.9 mmHg and the time of recovery to 5.7 +/- 1.7 min. The extravasation of 125I-bovine serum albumin under the above conditions was reduced by BN 52021 from 36 +/- 3 to 18 +/- 3%. A lower dose of BN 52021 (1 mg/kg, i.v.) was also effective in reducing later extravasation, but was unable to prevent the extravasation which appears up to 10 min after the injection of paf-acether. To extend these findings to a model of endogenous production of paf-acether, other animals were challenged with soluble aggregates of human IgG (40 mg/kg, i.v.; Iñarrea et al., Immunopharmacology 6:7, 1983).(ABSTRACT TRUNCATED AT ...Continue Reading


Oct 29, 1979·Biochemical and Biophysical Research Communications·M L BlankE E Muirhead
Feb 1, 1985·Immunopharmacology·P IñarreaM Sánchez-Crespo
Jan 1, 1966·International Archives of Allergy and Applied Immunology·P J McConahey, F J Dixon
Apr 25, 1983·Life Sciences·Z TerashitaK Nishikawa
Oct 15, 1984·European Journal of Pharmacology·P IñarreaM S Crespo
Jan 21, 1983·European Journal of Pharmacology·P BessinJ Benveniste


Dec 1, 1991·Lipids·R RabinoviciG Feuerstein
Sep 23, 1987·European Journal of Pharmacology·D A HandleyR N Saunders
Jan 1, 1992·British Journal of Pharmacology·S Fernández-GallardoM Sánchez Crespo
Aug 4, 2006·The Journal of Clinical Investigation·Anje CauwelsPeter Brouckaert
Jul 8, 1998·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·E B LoucksA K Qayumi
Oct 5, 2010·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Sergei I MalekinSergei N Orlov
Jun 30, 2006·Journal of Neurochemistry·Rebecca HawthorneJoseph W Lynch
Aug 1, 1986·Pharmacological Research Communications·Mariano Sánchez CrespoS Fernandez-Gallardo
Dec 1, 1989·Resuscitation·D HosfordP Braquet
Jan 5, 2005·Trends in Immunology·Sonia Jancar, Mariano Sánchez Crespo
Oct 4, 2000·Physiological Reviews·G MontrucchioG Camussi

Related Concepts

Related Feeds


Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.