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Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds

Free Radical Biology & Medicine

Sep 1, 2005

Anne-Barbara WitteElias S.J. Arner

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Abstract

Mammalian thioredoxin reductase (TrxR) is important for cell proliferation, antioxidant defense, and redox signaling. Together with glutathione reductase (GR) it is the main enzyme providing reducing equivalents to many cellular processes. GR and TrxR are flavoproteins of the same enzym...read more

Mentioned in this Paper

NSC-119875
Enzymes, antithrombotic
Glutathione Reductase
Platinum-containing Compounds [Chemical/Ingredient]
Platinol
Enzymes, peripheral vasodilators
Thioredoxin (human)
Antineoplastic Agents
Inactivation
Dye Exclusion Assays, Antitumor
Paper Details
References
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  • Citations98
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  • References45
  • Citations98
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Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds

Free Radical Biology & Medicine

Sep 1, 2005

Anne-Barbara WitteElias S.J. Arner

PMID: 16085187

DOI: 10.1016/j.freeradbiomed.2005.04.025

Abstract

Mammalian thioredoxin reductase (TrxR) is important for cell proliferation, antioxidant defense, and redox signaling. Together with glutathione reductase (GR) it is the main enzyme providing reducing equivalents to many cellular processes. GR and TrxR are flavoproteins of the same enzym...read more

Mentioned in this Paper

NSC-119875
Enzymes, antithrombotic
Glutathione Reductase
Platinum-containing Compounds [Chemical/Ingredient]
Platinol

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Paper Details
References
  • References45
  • Citations98
12345
  • References45
  • Citations98
12345...

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