PMID: 9437395Jan 23, 1998Paper

Inhibition of tooth eruption in the rat by a bisphosphonate

Journal of Dental Research
R L Grier, G E Wise

Abstract

Studies of osteopetrotic rodents suggest that localized alveolar bone resorption must occur if the tooth is to erupt. To test this hypothesis directly, we injected postnatal rats with pamidronate, a bisphosphonate that reduces bone resorption by osteoclasts. The results of these experiments demonstrate that this bisphosphonate inhibits the time of tooth eruption of both rat molars and incisors. Pamidronate does not inhibit the gene expression of the putative tooth eruption molecules, colony-stimulating factor-1 and c-fos, both of which are expressed in the dental follicle, the tissue that is required for eruption to occur. Pamidronate does increase the size of the osteoclasts, including an increase in the number of nuclei, suggesting that the precursor mononuclear cells can still fuse to form osteoclasts despite the reduced ability of the osteoclasts to resorb bone. Thus, we report the discovery of an agent that inhibits tooth eruption and also show that tooth eruption requires alveolar bone resorption.

References

Jan 1, 1980·Calcified Tissue International·C M PlasmansT J Slooff
Sep 1, 1995·Journal of Dental Research·G E WiseL Zhao
Oct 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K T Sundquist, S C Marks
Jan 1, 1995·Journal of Dental Research·G E Wise, F Lin
Oct 1, 1993·Calcified Tissue International·S J Wimalawansa, R D Gunasekera
Jan 1, 1993·Calcified Tissue International·M J MarshallM W Davie
Oct 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D E HughesB F Boyce
Aug 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R S Weinstein

❮ Previous
Next ❯

Citations

Sep 29, 2007·Cell and Tissue Research·Vivian Bradaschia-CorreaVictor E Arana-Chavez
May 14, 2009·Journal of Bone and Mineral Metabolism·Hisato HikitaShigemi Goto
Mar 5, 2003·Archives of Oral Biology·Gary E Wise, Shaomian Yao
Mar 15, 2001·Biomaterials·M YoshinariS Yokose
Jun 21, 2007·L' Orthodontie française·Agnès S Kamoun-Goldrat, Martine F Le Merrer
Apr 25, 2008·Journal of Dental Research·G E Wise, G J King
Jan 4, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Miya YoshinoShin-Ichi Hayashi
Jun 3, 2011·The Angle Orthodontist·Letitia E RandallSarandeep S Huja
Dec 3, 2014·Homo : internationale Zeitschrift für die vergleichende Forschung am Menschen·Krishan Sharma
Feb 20, 2016·Environmental Toxicology and Pharmacology·Ana Prates SoaresAlexandre Ribeiro do Espírito Santo
Nov 26, 2015·Frontiers in Physiology·Andrea GamaFrédéric Lézot
May 21, 2003·Clinical Oral Implants Research·Victoria Franke StenportShinichiro Oida
Nov 12, 2005·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Gary E WiseDawen Liu
Sep 8, 2011·European Journal of Oral Sciences·Gary E WiseShaomian Yao
Apr 5, 2011·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·H I YooS H Kim
Sep 3, 2005·Archives of Oral Biology·J HeinrichS Abboud
Jun 27, 2015·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·F VaysseS Cousty
Jul 3, 2009·The Journal of the American Dental Association·Brian Hodgson
Jul 28, 2013·Reproductive Toxicology·Jeanine L BussiereGary Chellman
Oct 12, 2013·Archives of Oral Biology·P A FontanettiN T Vermouth
Oct 26, 2016·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Magali HernandezDominique Droz
Mar 26, 2003·Journal of Dental Research·G E WiseS Yao
Aug 23, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·G E WiseR N D'Souza
Aug 27, 1998·Journal of Dental Research·G E Wise
Feb 24, 2001·Journal of Dental Research·G E WiseQ Zhang
Apr 13, 2001·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·G E WiseQ Zhang
Dec 16, 2017·Journal of Dental Research·V Thumbigere-MathB L Foster
Jan 18, 2017·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Nicole ChengChristine Hong
Jan 11, 2018·Laboratory Animals·Balazs J DenesStavros Kiliaridis
Jul 22, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·B G Que, G E Wise
Oct 2, 2004·European Journal of Oral Sciences·G E WiseS Yao
Dec 23, 2006·European Journal of Oral Sciences·Gary E Wise, Shaomian Yao
May 13, 2008·European Journal of Oral Sciences·Agnès Kamoun-GoldratMartine Le Merrer
Mar 18, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Hisashi SeshimaYutaka Oda
Mar 12, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Zeeshan SheikhMichael Glogauer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.