Inhibition of toxic activities of Bothrops asper venom and other crotalid snake venoms by a novel neutralizing mixture

Toxicology and Applied Pharmacology
G BorkowM Ovadia

Abstract

The majority of snake bites in Central America are caused by Bothrops asper, whose venom induce complex local effects such as myonecrosis, edema and especially hemorrhage. These effects are only partially neutralized by the clinically used antivenom, even when administered rapidly after envenomation. Recently we screened 49 substances for antihemorrhagic activity and found that a mixture composed of CaNa2, EDTA, a B. asper serum fraction (natural antidote), and the currently used horse polyvalent antiserum is highly effective in the neutralization of local and systemic hemorrhage developing after B. asper envenomation (Borkow et al., Toxicon 35, 865-877, 1997). In the present study we screened the best six antihemorrhagic compounds for their capacity to neutralize the lethal activity in mice and the proteolytic, hemolytic, and antiattachment activities in vitro of the venom. The compounds tested included the currently used horse antivenom, rabbit antiserum against whole B. asper venom or against heated venom, B. asper and Natrix tessellata serum fractions, and CaNa2 EDTA. The constituents of the antihemorrhagic mixture were also the best inhibitors of the other examined toxic activities. Importantly, the mixture effectively neu...Continue Reading

Citations

Mar 30, 2017·Bioorganic & Medicinal Chemistry Letters·Fabian Villalta-RomeroLjubica Tasic
Aug 8, 2008·Immunopharmacology and Immunotoxicology·Elda E Sánchez, Alexis Rodríguez-Acosta
May 8, 2021·Biomaterials Science·Xinyan ChengXiaolei Wang
Mar 1, 2000·Toxicon : Official Journal of the International Society on Toxinology·S L RochaJ Perales
Apr 5, 2003·Toxicon : Official Journal of the International Society on Toxinology·Carolina BattellinoSandra H P Farsky
Apr 22, 2006·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·C D Raghavendra GowdaB S Vishwanath
May 30, 2006·Toxicon : Official Journal of the International Society on Toxinology·André Gustavo C BonavitaPatrícia M R e Silva
Mar 28, 2009·Toxicon : Official Journal of the International Society on Toxinology·Bruno LomonteVitelbina Núñez

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