PMID: 8600461Mar 1, 1996Paper

Inhibition of transcription factor IIIA-DNA interactions by xenobiotic metal ions

Nucleic Acids Research
J S Hanas, C G Gunn

Abstract

Transcription factor IIIA (TFIIIA), a cysteine-rich regulatory protein, is the prototype for the largest known superfamily of eukaryotic transcription factors. Members of the TFIIIA superfamily contain Cys2His2 zinc finger domains responsible for nucleic acid binding. Xenobiotic metal ions, which lack known biological function, were previously used as probes for the structure and function of steroid hormone receptors which contain Cys2Cys2 zinc finger domains. Structural alterations in cysteine-rich regulatory proteins by such ions in vivo might potentiate carcinogenesis and other disease processes. In the present study cadmium and other xenobiotic metal ions were used to probe the structure and function of TFIIIA. The specific interaction of TFIIIA with the internal control region (ICR) of the 5S RNA gene, as assayed by DNase I protection, was inhibited by Cd2+ ion concentrations of > or = 0.1 microM. Aluminum ions were also found to inhibit the TFIIIA-5S RNA gene interaction, albeit at higher concentrations (> or = 5 microM). Inhibition by either metal ion was not readily reversible. Other xenobiotic metal ions, such as mercury or cesium, were not found to be inhibitory under these conditions. None of these ions at the concen...Continue Reading

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Citations

Jan 12, 2000·Journal of Biochemical and Molecular Toxicology·L E Rikans, T Yamano
Apr 15, 2009·Archives of Environmental Contamination and Toxicology·Ming-Hua Wang, Gui-Zhong Wang
Nov 26, 2002·Biochemical Pharmacology·Jason L LarabeeJay S Hanas
Aug 20, 2004·Biology of Reproduction·Angelique Vetillard, Thierry Bailhache
Apr 20, 2005·Journal of Bacteriology·Anyou Wang, David E Crowley
Mar 26, 2004·Journal of Inorganic Biochemistry·Meilin HuangDavid H Petering
Jan 22, 2011·Metallomics : Integrated Biometal Science·Susana M QuintalNicholas P Farrell
Sep 29, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Jamie L MichalekSarah L J Michel
Feb 3, 2009·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Ming ChangYuan Liu
Jun 9, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Myrian ColomboJacques Bernier
Jan 5, 2005·Archives of Biochemistry and Biophysics·Jason L LarabeeJay S Hanas
May 30, 2001·Biochemical Pharmacology·J S RodgersJ S Hanas
Aug 16, 2006·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Luqing Pan, Hongxia Zhang
May 9, 2006·Toxicology and Applied Pharmacology·Constantinos GiaginisStamatios Theocharis
May 1, 1997·Toxicology and Applied Pharmacology·S LynnK Y Jan
Nov 30, 2013·Metallomics : Integrated Biometal Science·Gaetano MalgieriCarla Isernia
Oct 1, 2014·Journal of Toxicology and Environmental Health. Part a·Eşref DemirRicard Marcos
Jan 9, 2016·Metallomics : Integrated Biometal Science·Jacqueline Michelle Ordemann, Rachel Narehood Austin
Oct 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·S MayaDivakar Goli
Sep 18, 2016·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Lyda Espitia-PérezJoão A P Henriques
Jun 22, 2000·Biology of Reproduction·R L GuévelF Pakdel
Aug 2, 2017·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·T Theophanides, J Anastassopoulou
Oct 26, 1999·Molecular Pharmacology·J S HanasY G Cheng
Jun 16, 2018·Inorganic Chemistry·Karine MazmanianCarmay Lim

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