Inhibition of transcriptional activities of AP-1 and c-Jun by a new zinc finger protein ZNF394

Biochemical and Biophysical Research Communications
Chunxia HuangXiushan Wu

Abstract

Zinc finger proteins play important roles in a variety of cellular functions, including cell growth, proliferation, apoptosis, and intracellular signal transduction, and the zinc finger-containing transcription factor has been implicated as a critical regulator of multiple cardiac-expressed genes as well as a regulator of inducible gene expression in response to hypertrophic stimulation. With the aim of identifying the genes involved in human heart development and diseases, we have isolated a novel LER-related zinc finger gene named ZNF394 from human heart cDNA library. ZNF394 gene has a predicted 561-amino acid open reading frame, encoding a 64kDa zinc finger protein. The N-terminus of ZNF394 protein has a leucine-rich region (LER or SCAN domain), followed by a well-conserved krüppel-associated box domain. The C-terminus of the protein contains 7 C2H2 zinc finger motifs in tandem arrays with the highly conserved space region of the H/C-link. ZNF394 gene is mapped to chromosome 7q11.21. Northern blot analysis indicates that a 2.18kb transcript specific for ZNF394 is specifically expressed in the heart, skeletal muscle, and brain in human adult tissues. ZNF394 protein is expressed in cell nucleus. Overexpression of ZNF394 in the...Continue Reading

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Citations

Jun 14, 2005·Biochemical and Biophysical Research Communications·Hong YangMingyao Liu
Jun 21, 2005·Biochemical and Biophysical Research Communications·Ying OuMingyao Liu
Jul 30, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Frank BoellmannRussell S Thomas
Jul 19, 2012·Biochemistry. Biokhimii︠a︡·S V RazinO L Kantidze
Oct 23, 2009·Annals of the New York Academy of Sciences·Jean-Nicolas Volff
Jun 7, 2005·Biochemical and Biophysical Research Communications·Fang LiuMingyao Liu
Sep 8, 2004·Biochemical and Biophysical Research Communications·Yuequn WangMingyao Liu
Jun 24, 2006·Biochemical and Biophysical Research Communications·Xinqiong HuangXiushan Wu
Jul 4, 2006·Biochemical and Biophysical Research Communications·Zhiming XiangYongqing Li
Dec 14, 2005·Biochemical and Biophysical Research Communications·Xingzhu QiXiushan Wu
Nov 24, 2004·Biochemical and Biophysical Research Communications·Yuequn WangXiushan Wu
Nov 23, 2013·Biochimica Et Biophysica Acta·Krithika RajagopalanPrakash Kulkarni
Dec 31, 2019·NAR Genomics and Bioinformatics·Laura Martinez-GomezMichael L Tress
Dec 18, 2007·Molecular and Cellular Biochemistry·Yongqing LiXiushan Wu
Nov 8, 2006·Molecular Biology Reports·Yongqing LiXiushan Wu

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