Inhibition of transplant coronary arteriosclerosis in rabbits by chronic estradiol treatment is associated with abolition of MHC class II antigen expression

Circulation
H LouM L Foegh

Abstract

Accelerated coronary arteriosclerosis is a major complication in long-term survivors of cardiac transplantation. Estrogen prevents transplant arteriosclerosis in experimental cardiac and aortic allografts and may act by an immune mechanism. New Zealand White rabbits immunosuppressed with cyclosporine were recipients of cardiac allografts from Dutch Belted rabbits. The recipients received either estradiol or placebo daily until they were killed 6 weeks later. Histological cross sections of the cardiac allograft were used for quantification of major histocompatibility complex (MHC) class II antigen expression, T lymphocytes, and macrophages by immunohistochemistry using monoclonal antibodies. MHC class II antigen expression was not detectable in allograft coronary arteries from any of the estradiol-treated recipients, whereas this antigen expression was present in the allograft coronary arteries from all the placebo-treated recipients. Macrophage and lymphocyte infiltration of the allograft coronary artery myointima was significantly less frequent in the estradiol-treated group. Rejection was moderate but slightly less in the estradiol-treated group. These findings were associated with a 60% decrease in allograft coronary artery ...Continue Reading

References

Mar 1, 1992·The Journal of Experimental Medicine·R OkuyamaK Kumagai
Jun 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·C DeboutJ Izard
Sep 1, 1990·The Journal of Clinical Endocrinology and Metabolism·S S TabibzadehP G Satyaswaroop
Nov 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J ThybergB A Bottger
Mar 1, 1993·Clinical Immunology and Immunopathology·B H AthreyaW V Williams
May 23, 1994·Archives of Internal Medicine·F M SacksB W Walsh
Jul 1, 1993·British Journal of Pharmacology·R VargasP W Ramwell

❮ Previous
Next ❯

Citations

Nov 8, 2008·International Urology and Nephrology·Ramesh SaxenaXin J Zhou
Aug 24, 1999·Transplantation Proceedings·S SaitoH Koyanagi
Apr 23, 2003·Journal of the American College of Cardiology·Wanpen VongpatanasinIshwarlal Jialal
Mar 21, 1998·Transplant Immunology·M L Foegh, P W Ramwell
Dec 18, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·H SavolainenP Häyry
Nov 24, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·S SaitoM L Foegh
Mar 5, 1999·Clinical and Experimental Pharmacology & Physiology·S SaitoP W Ramwell
Sep 1, 1999·Kidney International·L C Paul
Jun 11, 1999·The New England Journal of Medicine·M E Mendelsohn, R H Karas
Jul 5, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Christoph MuellerRené Prêtre
Dec 25, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Balazs AntusUwe Heemann
Jan 27, 1998·Current Opinion in Nephrology and Hypertension·M L Foegh, P W Ramwell
Jan 25, 2005·Transplantation·Paulo N A MartinsStefan G Tullius
Apr 25, 2000·Annual Review of Medicine·M Weis, W von Scheidt
Feb 23, 2012·Journal of Molecular Endocrinology·Jerzy-Roch Nofer
Jan 7, 2006·Treatments in Endocrinology·Dileep V Menon, Wanpen Vongpatanasin
Oct 17, 2013·International Reviews of Immunology·Paulo Ney Aguiar MartinsJames F Markmann
Nov 5, 2013·Transplantation Proceedings·L C KobashigawaC N Bairey Merz
Jul 28, 2005·Journal of Neuroimmunology·Clara M PelfreyRichard A Rudick
Dec 17, 1997·The American Journal of Cardiology·K K KohR O Cannon
Apr 4, 1998·The Annals of Thoracic Surgery·C H SelzmanB C Cain
Apr 17, 2001·American Journal of Obstetrics and Gynecology·R A Wild, S E Reis
May 18, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Cameron G DensemNicholas H Brooks
May 27, 1999·Research in Nursing & Health·B St Pierre SchneiderJ G Cannon
Jan 26, 2002·International Journal of Health Services : Planning, Administration, Evaluation·V F Meyer
Aug 23, 2003·Molecular Endocrinology·Eleni TzortzakakiJoseph Papamatheakis
Feb 22, 2001·American Journal of Physiology. Renal Physiology·R K Dubey, E K Jackson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.