Inhibition of TREM-1 attenuates inflammation and lipid accumulation in diet-induced nonalcoholic fatty liver disease

Journal of Cellular Biochemistry
Shenzong RaoXueliang Lu

Abstract

In the liver tissues of obese diabetic or nondiabetic patients, triggering receptor expressed on myeloid cells-1 (TREM-1) is usually found to be upregulated, thus leading to upregulation of various inflammatory cytokines and lipid accumulation. On the other hand, nonalcoholic fatty liver disease (NAFLD), characterized by excess lipid accumulation, and inflammatory injury in liver, is becoming an epidemic disease, globally. In the present study, we aimed to investigate the biological role and the underlying mechanisms of TREM-1 in NAFLD. upregulation of TREM-1 occurred in high-fat diet (HFD)-induced mice NAFLD model and oleic acid-treated HepG2 and primary mouse hepatocytes cell model at messenger RNA and protein levels. Functional studies established that overexpression of TREM-1 displayed hyperlipidemia, and increased in inflammatory indicators and lipid accumulation-related genes, which was ameliorated by knockdown of TREM-1. Our results also showed that obvious lipid accumulation and inflammatory injury occurred in the liver tissue of HFD-fed mice, while treatment with lentiviral vector short hairpin TREM showed marked improvement in tissue morphology and architecture and less lipid accumulation, thus deciphering the mechani...Continue Reading

References

Apr 18, 1998·Gastroenterology·C P Day, O F James
May 1, 2001·Nature Medicine·C Nathan, A Ding
Nov 21, 2001·Digestive Diseases and Sciences·V NehraK D Lindor
Jul 20, 2002·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·I Tavares de AlmeidaM E Camilo
Mar 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joshua R BleharskiRobert L Modlin
Feb 27, 2004·The American Journal of Clinical Nutrition·Charles S LieberLeonore M DeCarli
Apr 25, 2007·Blood·Philipp HaselmayerMarkus P Radsak
Aug 8, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Swati Joshi-BarveCraig J McClain
Feb 24, 2009·Journal of Hepatology·Francisco CaballeroCarmen García-Ruiz
Jan 19, 2010·Annual Review of Pathology·Dina G TiniakosElizabeth M Brunt
Nov 3, 2010·Human Molecular Genetics·David JelinekWilliam S Garver
Nov 3, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Herbert Tilg, Alexander R Moschen
Jan 20, 2011·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Peng LiMichael S Roberts
Apr 14, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Timea CsakGyongyi Szabo
Jun 11, 2011·Blood·Tereza OrmsbyAdelheid Cerwenka
May 31, 2012·Bosnian Journal of Basic Medical Sciences·Yu-Shi WangWai-Ou Zhao
Mar 20, 2013·Mediators of Inflammation·Débora EstadellaAline de Piano
Jul 3, 2013·International Immunopharmacology·Jiangang ZhouJun Shi
Aug 28, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Lake LiXiaogang Weng
Nov 7, 2013·International Journal of Molecular Sciences·Kento ImajoAtsushi Nakajima
Aug 12, 2014·Gastroenterology·Matthew M Yeh, Elizabeth M Brunt
Jan 27, 2015·Journal of Gastroenterology and Hepatology·Wataru TomenoAtsushi Nakajima
Apr 5, 2015·Circulation Research·Amir BoufenzerSébastien Gibot
Apr 29, 2015·Journal of Hepatology·Vlad RatziuArun Sanyal
Jun 16, 2015·Progress in Lipid Research·Joost WillebrordsMathieu Vinken
Oct 24, 2015·Arteriosclerosis, Thrombosis, and Vascular Biology·Annie DemersGaetan Mayer
Dec 17, 2015·Annual Review of Physiology·Joel T HaasBart Staels
Jan 23, 2016·Nature Reviews. Drug Discovery·Giovanni MussoRoberto Gambino
Sep 14, 2016·Oncoimmunology·Amir A Al-KhamiAugusto C Ochoa
Oct 21, 2016·Nature Communications·Daniel ZyssetChristoph Mueller
Dec 10, 2016·Biochemical and Biophysical Research Communications·Jianfei Tang, Qirong Dong
Apr 30, 2017·Journal of Translational Medicine·Saravanan SubramanianKalyana C Nandipati
Jun 28, 2017·World Journal of Hepatology·Mark Benedict, Xuchen Zhang
Jan 1, 2016·Clinical Medicine Insights. Therapeutics·Bubu A Banini, Arun J Sanyal
Sep 21, 2017·Nature Reviews. Gastroenterology & Hepatology·Zobair YounossiElisabetta Bugianesi
Dec 17, 2017·Journal of Gastroenterology·Yoshio Sumida, Masashi Yoneda
Jun 23, 2018·Annals of Medicine·Aki Juhani KäräjämäkiOlavi Ukkola

❮ Previous
Next ❯

Methods Mentioned

BETA
electrophoresis
PCR
PMH
biopsies

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.