PMID: 8951929Oct 1, 1996Paper

Inhibition of trigeminal neurons by intravenous administration of the serotonin (5HT)1B/D receptor agonist zolmitriptan (311C90): are brain stem sites therapeutic target in migraine?

Pain
P J Goadsby, Karen Lisa Hoskin

Abstract

Migraine is a common and debilitating condition. Its treatment has received considerable attention in recent times with the introduction into clinical use of the serotonin (5HT)1B/D-like agonist sumatriptan. It is known from human studies that the intracranial blood vessels and dura mater are important pain-sensitive structures since mechanical or electrical stimulation of these vessels, such as the superior sagittal sinus, causes pain. We have developed a model of craniovascular pain by stimulating the superior sagittal sinus and monitoring trigeminal neuronal activity using electrophysiological techniques. In this study we determined the effect of intravenous administration of the novel anti-migraine compound zolmitriptan (311C90) upon evoked neuronal activity in trigeminal neurons. Nine adult cats were anaesthetised with alpha-chloralose (60 mg/kg, i.p.; 20 mg/kg, i.v., 2-hourly) with all surgery being conducted under halothane (1-3%). The superior sagittal sinus was isolated for electrical stimulation. Recordings were made from caudal trigeminal neurons at the C2 level of the cervical spinal cord with tungsten-in-glass microelectrodes. Signals were amplified and analysed by a custom-written program that enabled software fil...Continue Reading

References

Aug 1, 1991·The New England Journal of Medicine·UNKNOWN Subcutaneous Sumatriptan International Study Group
Jan 1, 1991·European Neurology·P P HumphreyM L Tucker
Sep 28, 1991·Lancet·P J GoadsbyJ W Lance
Jan 1, 1985·Brain Research Bulletin·J T KellerJ G Jollis
Dec 1, 1994·Cephalalgia : an International Journal of Headache·P P Humphrey, P J Goadsby
Jan 1, 1993·Annual Review of Medicine·M A Moskowitz, F M Cutrer
Jun 1, 1993·Cephalalgia : an International Journal of Headache·C T O'ShaughnessyW Feniuk
Jun 1, 1960·Neurology·W FEINDELF McNAUGHTON

❮ Previous
Next ❯

Citations

May 25, 2010·Current Pain and Headache Reports·Marino Muxfeldt BianchinMarcelo Eduardo Bigal
Nov 16, 2013·CNS Drugs·Inger Jansen-OlesenJes Olesen
Jun 5, 1997·European Journal of Pharmacology·M J CumberbatchR J Hargreaves
Aug 12, 1999·European Journal of Pharmacology·P De VriesP R Saxena
Apr 18, 1998·Lancet·M D Ferrari
Aug 23, 2002·Pharmacology & Therapeutics·Paul L Durham, Andrew F Russo
Mar 14, 2001·Brain Research. Brain Research Reviews·D D Mitsikostas, M Sanchez del Rio
Jun 28, 2000·Progress in Neurobiology·P J Goadsby
Feb 13, 1999·Progress in Neurobiology·M J Millan
Jul 13, 1999·British Journal of Pharmacology·D D MitsikostasM A Moskowitz
Apr 22, 1999·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C DahlofK B Klein
May 19, 2000·Cephalalgia : an International Journal of Headache·G GeraudR Sweet
Aug 29, 2000·Cephalalgia : an International Journal of Headache·R H KemperG J Ter Horst
Apr 26, 2002·Cephalalgia : an International Journal of Headache·A J DowsonS L Levy
Apr 26, 2002·Cephalalgia : an International Journal of Headache·R UddmanL Edvinsson
Jun 17, 2005·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C VollonoG Di Trapani
Jul 22, 2005·Cephalalgia : an International Journal of Headache·M ZaletelT Pogacnik
Aug 30, 2008·Cephalalgia : an International Journal of Headache·L Edvinsson, P Tfelt-Hansen
Mar 3, 2009·Cephalalgia : an International Journal of Headache·J OlesenM Ashina
Sep 13, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Simon AkermanPeter J Goadsby

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.