PMID: 13549643Jul 1, 1958Paper

Inhibition of tuberculin skin hypersensitivity in guinea pigs by injection of tuberculin and intact tubercle bacilli during fetal life

The Journal of Experimental Medicine
D W WEISS

Abstract

FEMALE GUINEA PIGS WERE SUBJECTED TO LAPAROTOMY AT DIFFERENT STAGES OF PREGNANCY, AND THEIR FETUSES INJECTED THROUGH THE UTERINE WALLS WITH ONE OF THE FOLLOWING PREPARATIONS: Old Tuberculin, tubercle bacilli of the BCG strain killed by heat or exposure to phenol, and living BCG. A large number of the animals injected in utero with Old Tuberculin failed to develop skin hypersensitivity to P.P.D. following vaccination with 200 or 800 gamma phenol-killed tubercle bacilli (BCG) in early adulthood. Normal control animals were sensitized by vaccination with such quantities of phenolized BCG. The failure of animals which had been injected with Old Tuberculin in fetal life to respond hypersensitively to P.P.D. after adult vaccination with tubercle bacilli is ascribed to their acquisition of a state of immunological tolerance to tuberculoprotein (tuberculin tolerance). Fetal injection with killed BCG conferred a state of tolerance on a few of the animals, and rendered others tuberculin-sensitive. Fetal injection with living BCG sensitized most of the animals to tuberculin, even when fetal exposure was as early as 46 days before birth, and induced tolerance in none. Fetuses of the same litter, injected simultaneously with identical inocu...Continue Reading

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Citations

Apr 1, 1962·The Journal of Experimental Medicine·S B SALVINR F SMITH
Dec 1, 1967·Japanese Journal of Medical Science & Biology·T Yoshida
Feb 1, 1968·Japanese Journal of Medical Science & Biology·T Yoshida
Aug 1, 1984·The Journal of Surgical Research·R Superina, J L Meakins
Jan 1, 1963·Acta Pathologica Et Microbiologica Scandinavica·G BENDIXEN
Apr 1, 1990·Clinical Immunology and Immunopathology·V WicherS Nakeeb

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