PMID: 7539783Apr 1, 1995Paper

Inhibition of tumor-induced angiogenesis by a synthetic lipid A analogue with low endotoxicity, DT-5461

Japanese Journal of Cancer Research : Gann
K SatoI Azuma

Abstract

We investigated the effect of a synthetic lipid A analogue with low endotoxicity, DT-5461, on the neovascularization induced by B16-BL6 melanoma in syngeneic mice. A systemic single administration of DT-5461 caused a marked decrease in the number of vessels oriented toward the tumor mass and in the tumor size during the early phase of vasculogenesis (on day 4 after tumor inoculation), with little or no inhibition in the following phases. Multiple i.v. administrations of DT-5461 at intervals of 4 days (an effective schedule for inhibiting tumor metastasis) significantly reduced the number of capillary vessels and tumor growth over a period of 14 days after the tumor implantation. Multiple systemic administrations of DT-5461 on days 1, 5 and 9 after tumor inoculation caused a high production of endogenous tumor necrosis factor-alpha (TNF-alpha) in tumor sites although this treatment modality induced a low production in serum of tumor-bearing mice. Tumor homogenate from mice treated with DT-5461 suppressed the proliferation of endothelium in vitro, whereas sera from animals given DT-5461 had little effect. Furthermore, the antiproliferative effect of the tumor homogenate from mice treated with DT-5461, was completely abrogated by ...Continue Reading

References

Feb 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·D Gospodarowicz, K K Thakral
Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·E A CarswellB Williamson
Jan 1, 1992·Clinical Immunology and Immunopathology·C E SpoonerL D Saravolatz
Jan 1, 1992·Cancer Immunology, Immunotherapy : CII·E KumazawaY Osada
Oct 1, 1992·Japanese Journal of Cancer Research : Gann·K SatoI Azuma
May 1, 1991·The Journal of Experimental Medicine·T BlankensteinT Diamantstein
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M Fràter-SchröderP Böhlen
Aug 3, 1988·Journal of the National Cancer Institute·R A Kreisle, W B Ershler
Sep 1, 1989·Japanese Journal of Cancer Research : Gann·J MurataI Azuma
Nov 18, 1971·The New England Journal of Medicine·J Folkman
May 27, 1982·Nature·S Taylor, J Folkman
Nov 1, 1983·The Journal of Pathology·A M Schor, S L Schor
May 1, 1993·The Journal of Experimental Medicine·P OroszD N Männel

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Citations

Mar 27, 2007·European Journal of Pharmacology·Ricardo P GarayCarlo Chiavaroli
Mar 14, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Danièle ReisserJean-François Jeannin
Jul 11, 2003·Anti-cancer Drugs·Eun Kyung WonMichael R Chicoine
Jul 4, 2003·The Journal of Organic Chemistry·Sanjay K SinghRichard A Gross

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