PMID: 2489085Aug 1, 1989Paper

Inhibition of tumour cell adhesion by anti-metastatic polypeptide containing a repetitive Arg-Gly-Asp sequence

International Journal of Biological Macromolecules
J MurataS Tokura

Abstract

Anti-cell adhesive activity was examined by the synthetic polypeptide, containing repetitive Arg-Gly-Asp sequence of cell attachment site from fibronectin, poly (Arg-Gly-Asp). The attachment of tumour cells to fibronectin substrate was specifically inhibited by adding poly (Arg-Gly-Asp) in cell surface receptor-mediated and divalent cation-dependent manners, but not by unrelated peptides. In our previous study, the lung metastatic formation of tumour cells was dramatically reduced by intravenous co-injection of anti-cell adhesive poly (Arg-Gly-Asp) with B16-BL6 melanoma cells. These findings suggest that polypeptide-mediated inhibition of pulmonary metastasis is partly due to interference with tumour cell adhesion to the substrates including fibronectin in target organs or tissues.

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Citations

May 1, 1990·Japanese Journal of Cancer Research : Gann·J MurataI Azuma
Mar 1, 1994·Medicinal Research Reviews·D CoxK Yoshida
Sep 1, 1991·International Journal of Peptide and Protein Research·J MurataI Azuma
Jan 20, 1998·Japanese Journal of Pharmacology·I Saiki

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