Inhibition of tumour metastasis by targeted delivery of antioxidant enzymes

Expert Opinion on Drug Delivery
Makiya Nishikawa, Mitsuru Hashida

Abstract

Metastasis is one of the most harmful aspects of malignant neoplasm. Interaction of tumour cells with normal cells such as tissue macrophages may generate reactive oxygen species, which would affect various aspects of tumour metastasis. Reactive oxygen species cause damage to both tumour and normal cells and some of them, especially hydrogen peroxide, can also act as intracellular second messengers at sublethal concentrations to increase the transcription of various genes, which can then accelerate the proliferation of tumour cells in metastatic colonies. Therefore, eliminating hydrogen peroxide is one approach to inhibiting tumour metastasis. In this article, the roles of reactive oxygen species in tumour metastasis are reviewed, and the strategies to inhibit tumour metastasis by the targeted delivery of catalase, an enzyme that detoxifies hydrogen peroxide, are discussed.

References

Apr 1, 1990·Pharmaceutical Research·Y TakakuraH Sezaki
May 6, 1991·Biochimica Et Biophysica Acta·A R Cross, O T Jones
Mar 1, 1990·The New England Journal of Medicine·B R Zetter
Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D TrigueroW M Pardridge
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·I U SchraufstatterC G Cochrane
Nov 5, 1971·Biochemical and Biophysical Research Communications·J C Rogers, S Kornfeld
Oct 1, 1983·Physiological Reviews·N Simionescu
Jan 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L W SeymourR Duncan
Apr 1, 1995·Free Radical Biology & Medicine·R H Burdon
Jun 1, 1993·Pharmaceutical Research·K MiharaM Hashida
Jul 9, 1993·International Journal of Cancer. Journal International Du Cancer·E Barbera-Guillem, L Weiss
Jul 30, 1993·International Journal of Cancer. Journal International Du Cancer·Y NonakaK Orita
Jan 11, 1993·FEBS Letters·G GregoriadisR Lifely
Jan 1, 1993·The Journal of Antimicrobial Chemotherapy·R SettP K Das
May 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L G BayónS Meijer
May 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C K Sen, L Packer
Jan 1, 1996·Free Radical Biology & Medicine·Y Sun, L W Oberley
Sep 22, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·T NomuraM Hashida
Dec 5, 1998·Free Radical Biology & Medicine·C C ChuaB H Chua
Jun 25, 1999·Free Radical Biology & Medicine·M TakenagaY Mizushima
Mar 4, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·H MaedaK Hori
Mar 4, 2000·Free Radical Biology & Medicine·R G Allen, M Tresini
Jun 6, 2000·Advanced Drug Delivery Reviews·Y TakakuraM Hashida

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Citations

Mar 22, 2008·Clinical & Experimental Metastasis·Kenji HyoudouMitsuru Hashida
Mar 12, 2010·Pigment Cell & Melanoma Research·Arjen JoosseJan Willem W Coebergh
May 25, 2011·BMC Cancer·Jorming GohWarren Ladiges
Oct 14, 2011·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Vanessa BattistiVera M Morsch
Oct 13, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M K MuniyappaN Barron
Apr 14, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kenji HyoudouMitsuru Hashida
Mar 26, 2008·Cancer Letters·Makiya Nishikawa
Nov 27, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ramune RelieneRobert H Schiestl
Jul 27, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kenji HyoudouMitsuru Hashida
Nov 9, 2007·International Journal of Cancer. Journal International Du Cancer·Jun FangHiroshi Maeda
Sep 26, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chien-Hsun HuangJoen-Rong Sheu
Mar 18, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sun-Chae KimSung-Hoon Kim
Jan 20, 2015·Cancer Letters·Irene L IbañezHebe Durán
Jan 1, 2008·Clinical Medicine. Oncology·Ramune Reliene, Robert H Schiestl

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