PMID: 9186809May 1, 1997Paper

Inhibition of ultraviolet B-induced skin erythema by N-nitro-L-arginine and N-monomethyl-L-arginine

Journal of Dermatological Science
G DeliconstantinosJ C Stavrides

Abstract

Ultraviolet B (UVB)-irradiated human keratinocytes and human endothelial cells release nitrogen oxides, i.e. nitric oxide (NO). S-nitrosothiols, hydroxylamine (H2NOH) as well as ammonia (NH3) formed from L-arginine. Generation of these compounds was time and concentration-dependent and decreased by both N-monomethyl-L-arginine (L-NMMA) and N-nitro-L-arginine (L-NA). UVB radiation of the cells resulted in a concomitant increase of soluble guanylate cyclase (sGC) activity which was inhibited by L-NMMA and L-NA. S-nitrosothiols formed during the irradiation of the cells directly increased purified sGC activity by a mechanism characteristic of release of NO from a carried molecule. UVB-irradiated cells promptly increased thiobarbituric acid reacting substance (TBARS) (estimated as malondialdehyde. MDA) production which were inhibited by desferrioxamine. In in vivo experiments using guinea pigs subjected to UVB radiation, a Protection Factor (PF) of 2.25 +/- 0.75 was calculated when an emulsified cream formulation containing L-NMMA (1% w/w) and L-NA (1% w/w) was applied to their skin. In human volunteers subjected to UVB radiation, a dose-dependent increase of PF was observed. When an emulsified cream formulation containing L-NMMA (...Continue Reading

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Citations

Oct 31, 2001·Journal of Photochemistry and Photobiology. B, Biology·D A Brown
Mar 4, 2000·European Journal of Pain : EJP·R T Hoffmann, M Schmelz
Jul 10, 2002·Experimental Dermatology·László VirágCsaba Szabó
Jun 5, 2007·Burns : Journal of the International Society for Burn Injuries·Dimitrios FilippouEvangelos Manolis
Nov 6, 2002·Biochemical Pharmacology·Runa SurJeffrey D Laskin
Jun 22, 2013·International Journal of Radiation Biology·Igor Khalin, Ganna Kocherga
Sep 3, 2010·International Journal of Radiation Biology·Alena Svobodová, Jitka Vostálová
Sep 16, 1999·Critical Reviews in Clinical Laboratory Sciences·S H Francis, J D Corbin
Jul 28, 2004·Nitric Oxide : Biology and Chemistry·M-M Cals-Grierson, A D Ormerod
Mar 13, 2020·Histochemistry and Cell Biology·Milena T PelegrinoRichard B Weller

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